ArticleClinical and experimental gastroenterology2011
Treating acid reflux disease in patients with Down syndrome: pharmacological and physiological approaches.
Article in Clinical and experimental gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Tooth wear prevalence in individuals with Down syndrome: a systematic review.Clinical oral investigations · 2023Pooled it
- Advanced esophageal adenocarcinoma in a pediatric patient with Down syndrome: a rare case report and literature review.Annals of medicine and surgery (2012) · 2026Article
- Prevalence, associated risk factors, and respiratory event distribution of obstructive sleep apnea in children with Down syndrome.Sleep & breathing = Schlaf & Atmung · 2024Article
- Effect of trisomy 21 on long-term gastrointestinal outcomes in duodenal atresia.Pediatric surgery international · 2023Article
- Sleep and behavioral problems in Down syndrome: differences between school age and adolescence.Frontiers in psychiatry · 2023Article
- Single-minded 2 is required for left-right asymmetric stomach morphogenesis.Development (Cambridge, England) · 2021Article
- The impact of obstructive sleep apnea on bronchiolitis severity in children with Down syndrome.Sleep medicine · 2021Article
- Outcomes in children with down syndrome and mild obstructive sleep apnea treated non-surgically.The Laryngoscope · 2020Article
- The use of proton pump inhibitors among older adults with intellectual disability: A cross sectional observational study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Underlying factors of recurrent infections in patients with down syndrome.Northern clinics of Istanbul · 2018Review
- Obstructive sleep apnea in patients with Down syndrome: current perspectives.Nature and science of sleep · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Down syndrome (DS) is often accompanied by gastrointestinal disease, occurring mainly in early infancy and frequently requiring therapy. Among motility disorders, the most frequent is gastroesophageal reflux disease (GERD), which may often be misdiagnosed because of its atypical manifestations. Early diagnosis of esophageal functional disorders is essential to prevent respiratory problems, growth retardation in children, weight loss in adults, and to establish the correct type of surgery if needed. Furthermore, the involvement of the enteric nervous system in the pathophysiology of GERD in DS is not yet completely understood but seems supported by much evidence. In fact DS is often associated with motor disorders and this evidence must be considered in the choice of therapy: in particular all options available to improve motility seem to be effective in these patients. The effectiveness of therapy is strictly related to the rate of mental impairment, so that modulating therapy is essential, especially in view of the severity of the neurological status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.