ArticleThe Pediatric infectious disease journal2011
Children with retinopathy-negative cerebral malaria: a pathophysiologic puzzle.
Article in The Pediatric infectious disease journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Admission Clinical and EEG Features Associated With Mortality and Long-term Neurologic and Cognitive Outcomes in Pediatric Cerebral Malaria.Neurology · 2023Article
- Neurological Complications of Malaria.Current neurology and neuroscience reports · 2022Review
- [Ocular changes as a diagnostic tool for malaria].Die Ophthalmologie · 2022Article
- Retinopathy-Positive Cerebral Malaria Is Associated With Greater Inflammation, Blood-Brain Barrier Breakdown, and Neuronal Damage Than Retinopathy-Negative Cerebral Malaria.Journal of the Pediatric Infectious Diseases Society · 2020Article
- Pathophysiology and neurologic sequelae of cerebral malaria.Malaria journal · 2020Review
- Article
- Clinical Comparison of Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria.The American journal of tropical medicine and hygiene · 2017Article
- Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding.Journal of thrombosis and haemostasis : JTH · 2015Article
- The pathogenesis of pediatric cerebral malaria: eye exams, autopsies, and neuroimaging.Annals of the New York Academy of Sciences · 2015Review
- Brain MRI of children with retinopathy-negative cerebral malaria.The American journal of tropical medicine and hygiene · 2014Article
- Seasonal differences in retinopathy-negative versus retinopathy-positive cerebral malaria.The American journal of tropical medicine and hygiene · 2013Article
- Acute brain MRI findings in 120 Malawian children with cerebral malaria: new insights into an ancient disease.AJNR. American journal of neuroradiology · 2012Article
- Article
- Malaria in children.Mediterranean journal of hematology and infectious diseases · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCerebral malaria, defined as otherwise unexplained coma in a patient with circulating parasitemia, is a common disease in the developing world. The clinical diagnosis lacks specificity and children with other underlying causes of coma might be misdiagnosed as having cerebral malaria. The presence of malarial retinopathy can be used to differentiate children whose comas are caused by Plasmodium falciparum and its attendant pathophysiologies from those with other reasons for their abnormal mental status. Children with cerebral malaria who lack malarial retinopathy have not previously been described.
methodsAll patients admitted to Queen Elizabeth Central Hospital in Blantyre, Malawi, during a 12-month period with a clinical diagnosis of cerebral malaria were evaluated for the presence of malarial retinopathy. Thirty-two patients lacked retinopathy findings. Clinical, laboratory, and radiologic information data were collected.
resultsThirty-two cases of retinopathy-negative cerebral malaria are presented.
conclusionsChildren with retinopathy-negative cerebral malaria share a common clinical phenotype with lower rates of mortality compared with those who have malarial retinopathy. There are at least 4 possible pathophysiologic explanations for this common condition.
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