ArticlemBio2011
High levels of recombination among Streptococcus pneumoniae isolates from the Gambia.
Article in mBio, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Streptococcus pneumoniae and other bacterial nasopharyngeal colonization seven years post-introduction of 13-valent pneumococcal conjugate vaccine in South African children.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Article
- AMicrobial genomics · 2022Article
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- Strategies to Attenuate the Competence Regulon inPeptide science (Hoboken, N.J.) · 2021Article
- Invasive Disease Caused Simultaneously by Dual Serotypes of Streptococcus pneumoniae.Journal of clinical microbiology · 2018Article
- Article
- The blp Locus of Streptococcus pneumoniae Plays a Limited Role in the Selection of Strains That Can Cocolonize the Human Nasopharynx.Applied and environmental microbiology · 2016Article
- Population structure, epidemiology and antibiotic resistance patterns of Streptococcus pneumoniae serotype 5: prior to PCV-13 vaccine introduction in Eastern Gambia.BMC infectious diseases · 2016Article
- Interim results of an ecological experiment - Conjugate vaccination against the pneumococcus and serotype replacement.Human vaccines & immunotherapeutics · 2016Review
- High multiple carriage and emergence of Streptococcus pneumoniae vaccine serotype variants in Malawian children.BMC infectious diseases · 2015Article
- Bacterial genomic epidemiology, from local outbreak characterization to species-history reconstruction.Pathogens and global health · 2015Review
- Multi-serotype pneumococcal nasopharyngeal carriage prevalence in vaccine naïve Nepalese children, assessed using molecular serotyping.PloS one · 2015Article
- The impact of natural transformation on adaptation in spatially structured bacterial populations.BMC evolutionary biology · 2014Article
- Dense genomic sampling identifies highways of pneumococcal recombination.Nature genetics · 2014Article
- The host immune dynamics of pneumococcal colonization: implications for novel vaccine development.Human vaccines & immunotherapeutics · 2014Review
- Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease.Frontiers in cellular and infection microbiology · 2014Review
- Influence of bacterial interactions on pneumococcal colonization of the nasopharynx.Trends in microbiology · 2013Review
- Inference on population histories by approximating infinite alleles diffusion.Molecular biology and evolution · 2013Article
- Molecular typing of the pneumococcus and its application in epidemiology in sub-Saharan Africa.Frontiers in cellular and infection microbiology · 2013Review
- Article
Corrections and comments
- Erratum issuedGould, K A [added]; Hinds, J [added]
Authors and funding
7 authors.
Funding
Abstract
We carried out multilocus sequence typing (MLST) on 148 pneumococcal carriage isolates collected from children <24 months old in the Upper River Division, the Gambia. MLST revealed a diverse population. Seventy-six different sequence types (STs) were found, the most common of which were 802 and 919, associated with 23F and 6A serotypes, respectively. Comparison with the MLST database showed that only 11 of the STs found in the present sample had been reported outside Africa. Six STs showed evidence of capsular switching (172, 802, 847, 1730, 1736, and 1737). Serotype switches were confirmed by microarrays that detected capsule genes. Of isolates analyzed by using microarrays, 40/69 (58%) harbored the tetM resistance determinant. A statistical genetic analysis to detect recombination found that 49/144 (34%) isolates showed significant (P<0.05) evidence of admixture, which is greater than that observed in similar samples from the United Kingdom (5%) and Finland (2%). We hypothesize that large amounts of admixture could reflect the high prevalence of multiple carriage in this region, leading to more opportunities for homologous recombination between strains. This could have consequences for the population response to conjugate vaccination.
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