Trial reportCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2011
Localized fibroglandular tissue as a predictor of future tumor location within the breast.
Trial report in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide.PLoS medicine · 2017Pooled it
- Mammographic density phenotypes and risk of breast cancer: a meta-analysis.Journal of the National Cancer Institute · 2014Pooled it
- The Influence of Vitamin D on Mammographic Density: Results from CALGB 70806 (Alliance) a Randomized Clinical Trial.Cancer prevention research (Philadelphia, Pa.) · 2021Trial
- Associations of local breast density with patient characteristics and risk of breast cancer among women undergoing diagnostic breast biopsy.Breast cancer research : BCR · 2026Article
- Assessing mammographic density change within individuals across screening rounds using deep learning-based software.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Breast density assessment via quantitative sound-speed measurement using conventional ultrasound transducers.European radiology · 2025Article
- Qualitative assessments of density and background parenchymal enhancement on contrast-enhanced spectral mammography associated with breast cancer risk in high-risk women.The British journal of radiology · 2023Article
- TNF-Alpha Promotes an Inflammatory Mammary Microenvironment That Favors Macrophage and Epithelial Migration in a CCL2- and Mitochondrial-ROS-Dependent Manner.Antioxidants (Basel, Switzerland) · 2023Article
- Independent and joint cross-sectional associations of statin and metformin use with mammographic breast density.Breast cancer research : BCR · 2020Article
- Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study.Breast cancer research : BCR · 2019Article
- Application of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast density.NPJ breast cancer · 2019Article
- 3D MRI for Quantitative Analysis of Quadrant Percent Breast Density: Correlation with Quadrant Location of Breast Cancer.Academic radiology · 2017Article
- Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants.BMC cancer · 2017Article
- Effect of Vitamin D Supplementation on Breast Cancer Biomarkers: CALGB 70806 (Alliance) Study Design and Baseline Data.American journal of hematology/oncology · 2016Article
- International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries.Cancer epidemiology · 2016Article
- Relationship of Terminal Duct Lobular Unit Involution of the Breast with Area and Volume Mammographic Densities.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Cyclic endogenous estrogen and progesterone vary by mammographic density phenotypes in premenopausal women.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2016Article
- Determinants of the reliability of ultrasound tomography sound speed estimates as a surrogate for volumetric breast density.Medical physics · 2015Article
- Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women.Breast cancer research : BCR · 2015Article
- Quantification of Regional Breast Density in Four Quadrants Using 3D MRI-A Pilot Study.Translational oncology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMammographic density (MD) is a strong marker of breast cancer risk, but it is unclear whether tumors arise specifically within dense tissue.
methodsIn 231 British women diagnosed with breast cancer after at least one negative annual screening during a mammographic screening trial, we assessed whether tumor location was related to localized MD 5 years prior to diagnosis. Radiologists identified tumor locations on digitised films. We used a validated algorithm to align serial images from the same woman to locate the corresponding point on the prediagnostic film. A virtual 1 cm square grid was overlaid on prediagnostic films and MD calculated for each square within a woman's breast (mean = 271 squares/film). Conditional logistic regression, matching on a woman's breast, was used to estimate the odds of a tumor arising in a square in relation to its prediagnostic square-specific MD.
resultsMedian (interquartile range) prediagnostic MD was 98.2% (46.8%-100%) in 1 cm-squares that subsequently contained the tumor and 41.0% (31.5%-53.9%) for the whole breast. The odds of a tumor arising in a 1 cm-square were, respectively, 6.1 (95% CI: 1.9-20.1), 16.6 (5.2-53.2), and 25.5-fold (8.1-80.3) higher for squares in the second, third, and fourth quartiles of prediagnostic MD relative to those in the lowest quartile within that breast (P(trend) < 0.001). The corresponding odds ratios were 2.3 (1.3-4.0), 3.9 (2.3-6.4), and 4.6 (2.8-7.6) if a 3 cm-square grid was used.
conclusionTumors arise predominantly within the radiodense breast tissue. IMPACT: Localized MD may be used as a predictor of subsequent tumor location within the breast.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.