ArticleJournal of cell science2011
A functional channel is necessary for growth suppression by Cx37.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- A novel cancer-associated fibroblast signature for kidney renal clear cell carcinoma via integrated analysis of single-cell and bulk RNA-sequencing.Discover oncology · 2024Article
- Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest.Life science alliance · 2023Article
- New Insights into Pulmonary Hypertension: A Role for Connexin-Mediated Signalling.International journal of molecular sciences · 2021Review
- Cutaneous and hepatic vascular lesions due to a recurrent somaticHGG advances · 2021Article
- Connexins in Cancer: Jekyll or Hyde?Biomolecules · 2020Review
- Serine 319 phosphorylation is necessary and sufficient to induce a Cx37 conformation that leads to arrested cell cycling.Journal of cell science · 2020Article
- Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer.Oncology letters · 2019Article
- Phosphorylation-Dependent Intra-Domain Interaction of the Cx37 Carboxyl-Terminus Controls Cell Survival.Cancers · 2019Article
- Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease.International journal of molecular sciences · 2018Review
- Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification.Nature communications · 2017Article
- Regulation of Cx37 channel and growth-suppressive properties by phosphorylation.Journal of cell science · 2017Article
- Determinants of Cx43 Channel Gating and Permeation: The Amino Terminus.Biophysical journal · 2016Article
- Structural determinants and proliferative consequences of connexin 37 hemichannel function in insulinoma cells.The Journal of biological chemistry · 2014Article
- Mutations of Cx43 that affect B cell spreading in response to BCR signaling.Biology open · 2014Article
- Possible role of hemichannels in cancer.Frontiers in physiology · 2014Article
- Carboxy terminus and pore-forming domain properties specific to Cx37 are necessary for Cx37-mediated suppression of insulinoma cell proliferation.American journal of physiology. Cell physiology · 2013Article
- Concise review: in search of unlimited sources of functional human pancreatic beta cells.Stem cells translational medicine · 2013Review
- Extracellular loop cysteine mutant of cx37 fails to suppress proliferation of rat insulinoma cells.The Journal of membrane biology · 2012Article
- Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transfer.The Journal of membrane biology · 2012Article
- Cx37 deletion enhances vascular growth and facilitates ischemic limb recovery.American journal of physiology. Heart and circulatory physiology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Connexin 37 (Cx37) profoundly suppresses the proliferation of rat insulinoma (Rin) cells by unknown mechanisms. To determine whether a functional pore domain is necessary for Cx37-mediated growth suppression, we introduced a mutation that converted threonine 154 into alanine (T154A). Like other connexins mutated at the homologous site, Cx37-T154A localized to appositional membrane but failed to form functional channels and exerted a dominant-negative effect on coexpressed wild-type Cx37 or Cx43. Unlike the wild-type protein, Cx37-T154A did not suppress the proliferation of Rin cells and did not, with serum deprivation, result in cell cycle arrest. Furthermore, progression through the cell cycle was unaffected by expression of Cx37-T154A. These results indicate that a pore-forming domain that is able to form functional channels is essential for the anti-proliferative, cell-cycle arrest and serum-sensitivity effects of Cx37, and furthermore that the normally localized C-terminal domain is not sufficient for these effects of Cx37.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.