ReviewMolecular and cellular endocrinology2011
The role of vitamin D receptor mutations in the development of alopecia.
Review in Molecular and cellular endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03154528 (Role of Vitamin D in Androgenetic Alopecia), which is not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Vitamin D in Androgenetic Alopecia
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis.Frontiers in oral health · 2025Pooled it
- Vitamin D deficiency in non-scarring and scarring alopecias: a systematic review and meta-analysis.Frontiers in nutrition · 2024Pooled it
- Genotypic Spectrum and its Correlation with Alopecia and Clinical Response in Hereditary Vitamin D Resistant Rickets: Our Experience and Systematic Review.Calcified tissue international · 2023Pooled it
- A case of vitamin D-dependent rickets type 2A presenting with hypophosphatemia without hypocalcemia.JCEM case reports · 2026Article
- The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications.Journal of cell communication and signaling · 2026Review
- Article
- Dysregulation and gene polymorphisms of Vitamin D receptor: its implications in lipid metabolic disorders.Molecular biology reports · 2025Review
- Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin.International journal of molecular sciences · 2025Article
- Tru9I Variant as a Novel Genetic Marker for Vitamin D Deficiency in Alopecia Areata.Clinical, cosmetic and investigational dermatology · 2025Article
- Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin D signaling.Science advances · 2024Article
- Clinical characteristics and long-term management for patients with vitamin D-dependent rickets type II: a retrospective study at a single center in Saudi Arabia.Frontiers in endocrinology · 2024Article
- Characterization of Rickets Type II Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor.Biomolecules · 2023Article
- VDR is an essential regulator of hair follicle regression through the progression of cell death.Life science alliance · 2023Article
- Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector.Scientific reports · 2023Article
- Article
- Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats.Scientific reports · 2022Article
- Role of Neural Stem Cells and Vitamin D Receptor (VDR)-Mediated Cellular Signaling in the Mitigation of Neurological Diseases.Molecular neurobiology · 2022Review
- Regulation of calcific vascular and valvular disease by nuclear receptors.Current opinion in lipidology · 2019Review
- Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study.Clinical, cosmetic and investigational dermatology · 2019Article
- Genetics of Refractory Rickets: Identification of NovelJournal of pediatric genetics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hereditary Vitamin D Resistant Rickets (HVDRR) is a rare disease caused by mutations in the vitamin D receptor (VDR). The consequence of defective VDR is the inability to absorb calcium normally in the intestine. This leads to a constellation of metabolic abnormalities including hypocalcemia, secondary hyperparathyroidism and hypophosphatemia that cause the development of rickets at an early age in affected children. An interesting additional abnormality is the presence of alopecia in some children depending on the nature of the VDR mutation. The data indicate that VDR mutations that cause defects in DNA binding, RXR heterodimerization or absence of the VDR cause alopecia while mutations that alter VDR affinity for 1,25(OH)(2)D(3) or disrupt coactivator interactions do not cause alopecia. The cumulative findings indicate that hair follicle cycling is dependent on unliganded actions of the VDR. Further research is ongoing to elucidate the role of the VDR in hair growth and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.