ArticleCritical care (London, England)2011
The microbiological profile and presence of bloodstream infection influence mortality rates in necrotizing fasciitis.
Article in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Necrotising Fasciitis in Patients With Diabetes: A Systematic Review of Mortality-Associated Clinical Factors.International wound journal · 2026Pooled it
- Multifocal necrotizing fasciitis: what makes it different? A German trauma center experience.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Limited Diagnostic Value of Blood Cultures in Patients with Soft Tissue Infections Transferred to a Quaternary Care Center.Bioengineering (Basel, Switzerland) · 2025Article
- A Study on the Accuracy of Point-of-Care Ultrasound in the Diagnosis and Management of Necrotizing Fasciitis.Cureus · 2025Article
- Article
- Necrotizing fasciitis resembled acute coronary syndrome: A case report.Clinical case reports · 2024Article
- Impact of the COVID-19 Pandemic on Group A Streptococcal Necrotizing Soft Tissue Infections: A Retrospective Cohort Study.Open forum infectious diseases · 2024Article
- The Impact of Cefuroxime Susceptibility onMicroorganisms · 2023Article
- Rational Use of Antibiotics and Education ImprovedAntibiotics (Basel, Switzerland) · 2022Article
- Extensive monomicrobial necrotizing fasciitis and myonecrosis of left hemi trunk in a healthy 41-year-old man with COVID-19 infection.Iranian journal of microbiology · 2022Article
- Global outcomes and lessons learned in the management of Fournier's gangrene from high-volume centres: findings from a literature review over the last two decades.World journal of urology · 2022Review
- Necrotizing Soft Tissue Infections, the Challenge Remains.Frontiers in surgery · 2021Article
- Necrotizing fasciitis in haematological patients: a different scenario.Annals of hematology · 2020Article
- Patient's characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study.Intensive care medicine · 2019Article
- Clinical parameters and outcomes of necrotizing soft tissue infections secondary to gastrointestinal fistulas.BMC infectious diseases · 2019Article
- Multidrug-resistant Aeromonas hydrophila causing fatal bilateral necrotizing fasciitis in an immunocompromised patient: a case report.Journal of medical case reports · 2018Article
- Risk factors for mortality in the late amputation of necrotizing fasciitis: a retrospective study.World journal of emergency surgery : WJES · 2018Article
- Case report: role of bedside ultrasonography in early diagnosis of myonecrosis rapidly developed in deep soft tissue infections.Journal of ultrasound · 2016Article
- A Fatal Case of Necrotizing Fasciitis Caused by a Highly Virulent Escherichia coli Strain.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2016Article
- Necrotizing Fasciitis of the Abdominal Wall Caused by Serratia Marcescens.Infectious disease reports · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNecrotizing fasciitis (NF) is a life threatening infectious disease with a high mortality rate. We carried out a microbiological characterization of the causative pathogens. We investigated the correlation of mortality in NF with bloodstream infection and with the presence of co-morbidities.
methodsIn this retrospective study, we analyzed 323 patients who presented with necrotizing fasciitis at two different institutions. Bloodstream infection (BSI) was defined as a positive blood culture result. The patients were categorized as survivors and non-survivors. Eleven clinically important variables which were statistically significant by univariate analysis were selected for multivariate regression analysis and a stepwise logistic regression model was developed to determine the association between BSI and mortality.
resultsUnivariate logistic regression analysis showed that patients with hypotension, heart disease, liver disease, presence of Vibrio spp. in wound cultures, presence of fungus in wound cultures, and presence of Streptococcus group A, Aeromonas spp. or Vibrio spp. in blood cultures, had a significantly higher risk of in-hospital mortality. Our multivariate logistic regression analysis showed a higher risk of mortality in patients with pre-existing conditions like hypotension, heart disease, and liver disease. Multivariate logistic regression analysis also showed that presence of Vibrio spp in wound cultures, and presence of Streptococcus Group A in blood cultures were associated with a high risk of mortality while debridement > = 3 was associated with improved survival.
conclusionsMortality in patients with necrotizing fasciitis was significantly associated with the presence of Vibrio in wound cultures and Streptococcus group A in blood cultures.
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