Trial reportArthritis research & therapy2011
The association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a cross-sectional study.
Trial report in Arthritis research & therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- Trial
- A randomized controlled trial assessing the effects of raltegravir intensification on endothelial function in treated HIV infection.Journal of acquired immune deficiency syndromes (1999) · 2012Trial
- The role of inflammation and cardiovascular disease risk on microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a cross-sectional and longitudinal study.Arthritis research & therapy · 2012Trial
- Capillary Microvascular Dysfunction in Rheumatoid Arthritis: The Promising Role of Nailfold Videocapillaroscopy-A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Circulating vascular biomarkers in relation to physiological indices of aortic stiffness and endothelial function in hypertension.Scientific reports · 2025Article
- Oral contraceptive pill phase alters mechanisms contributing to cutaneous microvascular function in response to local heating.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Doppler Ultrasound Assessment of Blood Flow Indices in Childbearing Age Women Across the Menstrual Cycle.Medicina (Kaunas, Lithuania) · 2025Article
- Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study.Non-coding RNA · 2025Article
- Sema4D as a biomarker for Predicting rheumatoid arthritis disease activity.Clinical rheumatology · 2024Article
- Combined Effects of Diet and Physical Activity on Inflammatory Joint Disease: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2023Review
- Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Macro- and Microvascular Function in Middle-Aged Individuals with Low Cardiovascular Disease Risk.Journal of clinical medicine · 2022Article
- Study of Peripheral Microcirculation Assessed by Nailfold Video-Capillaroscopy and Association with Markers of Endothelial Dysfunction and Inflammation in Rheumatoid Arthritis.Mediterranean journal of rheumatology · 2022Article
- Orchiectomy but not adjuvant-induced arthritis induces structural modifications in rat aortas.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2022Article
- Ischemic Heart Disease and Rheumatoid Arthritis-Two Conditions, the Same Background.Life (Basel, Switzerland) · 2021Review
- Autoimmune Rheumatic Diseases and Vascular Function: The Concept of Autoimmune Atherosclerosis.Journal of clinical medicine · 2021Review
- Apixaban Downregulates Endothelial Inflammatory and Prothrombotic Phenotype in an In Vitro Model of Endothelial Dysfunction in Uremia.Cardiovascular drugs and therapy · 2021Article
- Statistical Inferences Using Effect Sizes in Human Endothelial Function Research.Artery research · 2021Article
- Review
- A prospective, longitudinal monocentric study on laser Doppler imaging of microcirculation: comparison with macrovascular pathophysiology and effect of adalimumab treatment in early rheumatoid arthritis.Rheumatology international · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
introductionPatients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One of the earliest manifestations of CVD is endothelial dysfunction (ED). ED can occur in both the microcirculation and the macrocirculation, and these manifestations might be relatively independent of each other. Little is known about the association between endothelial function in the microcirculation and the macrocirculation in RA. The objectives of the present study were to examine the relationship between microvascular and macrovascular endothelial function in patients with RA.
methodsNinety-nine RA patients (72 females, mean age (± SD) 56 ± 12 years), underwent assessments of endothelial-dependent (acetylcholine) and endothelial-independent (sodium nitroprusside) microvascular vasodilatory function (laser Doppler imaging with iontophoresis), as well as endothelial-dependent (flow-mediated dilation) and endothelial-independent (glyceryl trinitrate-mediated dilation) macrovascular vasodilatory function. Vasodilatory function was calculated as the percentage increase after each stimulus was applied relative to baseline values.
resultsPearson correlations showed that microvascular endothelial-dependent function was not associated with macrovascular endothelial-dependent function (r (90 patients) = 0.10, P = 0.34). Similarly, microvascular endothelial-independent function was not related to macrovascular endothelial-independent function (r (89 patients) = 0.00, P = 0.99).
conclusionsMicrovascular and macrovascular endothelial function were independent of each other in patients with RA, suggesting differential regulation of endothelial function in these two vascular beds. Assessments of both vascular beds may provide more meaningful clinical information on vascular risk in RA, but this hypothesis needs to be confirmed in long-term prospective studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.