ReviewJournal of cellular and molecular medicine2012
How do tenascins influence the birth and life of a malignant cell?
Review in Journal of cellular and molecular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- The Significance of the Microenvironment in T/Nk-Cell Neoplasms.International journal of molecular sciences · 2025Review
- Evaluation of Tenascin Expression in Ameloblastoma, Odontogenic Keratocyst, and Dentigerous Cyst by Immunohistochemistry.Advanced biomedical research · 2023Article
- Revisiting the Tenascins: Exploitable as Cancer Targets?Frontiers in oncology · 2022Review
- Article
- Emerging Roles of Matricellular Proteins in Systemic Sclerosis.International journal of molecular sciences · 2020Review
- Multiple Roles of Tenascins in Homeostasis and Pathophysiology of Aorta.Annals of vascular diseases · 2018Article
- Evaluation of tenascin-C by tenatumomab in T-cell non-Hodgkin lymphomas identifies a new target for radioimmunotherapy.Oncotarget · 2018Article
- Tenascin-C induces migration and invasion through JNK/c-Jun signalling in pancreatic cancer.Oncotarget · 2017Article
- Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization.Advanced drug delivery reviews · 2016Review
- Article
- Article
- Review
- Transcriptional regulation of tenascin-W by TGF-beta signaling in the bone metastatic niche of breast cancer cells.International journal of cancer · 2015Article
- Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling.Molecular oncology · 2015Article
- Voltage-gated sodium channels and cancer: is excitability their primary role?Frontiers in pharmacology · 2015Review
- Insidious changes in stromal matrix fuel cancer progression.Molecular cancer research : MCR · 2014Review
- SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients.Molecular cancer · 2014Article
- Priming cancer cells for drug resistance: role of the fibroblast niche.Frontiers in biology · 2014Article
- Tenascin-C and mechanotransduction in the development and diseases of cardiovascular system.Frontiers in physiology · 2014Review
- Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma.Cancer research · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tenascins are large glycoproteins found in embryonic and adult extracellular matrices. Of the four family members, two have been shown to be overexpressed in the microenvironment of solid tumours: tenascin-C and tenascin-W. The regular presence of these proteins in tumours suggests a role in tumourigenesis, which has been investigated intensively for tenascin-C and recently for tenascin-W as well. In this review, we follow a malignant cell starting from its birth through its potential metastatic journey and describe how tenascin-C and tenascin-W contribute to these successive steps of tumourigenesis. We consider the importance of the mechanical aspect in tenascin signalling. Furthermore, we discuss studies describing tenascin-C as an important component of stem cell niches and present examples reporting its role in cancer therapy resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.