Evidence map›Paper›PMID 21692661›Full record

ReviewAnnual review of neuroscience2011

The development and application of optogenetics.

Lief Fenno, Ofer Yizhar, Karl Deisseroth

Abstract readReview
In one paragraph

Review in Annual review of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 857 papers.

0numbers the graph read from it
0cells of the map it votes in
857citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

857 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Developing Optogenetic Approaches to Study CaCold Spring Harbor perspectives in biology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. The Importance of Synchrony in the Neural Control of Movement.bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs-cAMP Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  20. Article

797 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lief FennoDepartment of Bioengineering, Stanford University, Stanford, California 94305, USA.
Ofer Yizhar
Karl Deisseroth

Funding

OPTICAL NEUROMODULATION TECHNOLOGY FOR LONG TIMESCALESR01MH086373 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2010 to 2025
$9.1M
Calcium channels, newborn neurons, and CNS circuit dynamicsR01DA020794 · NIDA · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2005 to 2014
$4.1M
NIH Director's Pioneer Award (RMI)DP1OD000616 · OD · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2005 to 2009
$3.8M
Technology development for fast optical interrogation of living neural circuitryR01MH075957 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2008 to 2012
$2.6M
NIDA NIH HHS R01 DA020794NIH HHS DP1 OD000616NIMH NIH HHS R01 MH075957NIMH NIH HHS R01 MH086373
6 · The paper itself

Abstract

Genetically encoded, single-component optogenetic tools have made a significant impact on neuroscience, enabling specific modulation of selected cells within complex neural tissues. As the optogenetic toolbox contents grow and diversify, the opportunities for neuroscience continue to grow. In this review, we outline the development of currently available single-component optogenetic tools and summarize the application of various optogenetic tools in diverse model organisms.

Indexed as

AnimalsAnimals, Genetically ModifiedGenetic EngineeringHumansLight Signal TransductionModels, GeneticNerve NetNeural InhibitionNeuronsNeurosciencesOpsinsOpsins

Identifiers

PMID21692661
PMCPMC6699620

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.