ArticleHuman brain mapping2012
Transcranial magnetic stimulation and motor plasticity in human lateral cerebellum: dual effect on saccadic adaptation.
Article in Human brain mapping, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Probing cerebellar involvement in cognition through a meta-analysis of TMS evidence.Scientific reports · 2021Pooled it
- Ganzfeld stimulation or sleep enhance long term motor memory consolidation compared to normal viewing in saccadic adaptation paradigm.PloS one · 2015Trial
- Even with exposure to errors, motor imagery cannot update internal models.Psychological research · 2025Article
- A triple distinction of cerebellar function for oculomotor learning and fatigue compensation.PLoS computational biology · 2023Article
- Classics to Contemporary of Saccadic Dysmetria and Oscillations.Cerebellum (London, England) · 2023Article
- Impaired Saccade Adaptation in Tremor-Dominant Cervical Dystonia-Evidence for Maladaptive Cerebellum.Cerebellum (London, England) · 2021Article
- Saccadic adaptation shapes perceived size: Common codes for action and perception.Attention, perception & psychophysics · 2020Article
- Cortico-cerebellar network involved in saccade adaptation.Journal of neurophysiology · 2018Article
- After Effects of Cerebellar Continuous Theta Burst Stimulation on Reflexive Saccades and Smooth Pursuit in Humans.Cerebellum (London, England) · 2017Article
- Targeting the Cerebellum by Noninvasive Neurostimulation: a Review.Cerebellum (London, England) · 2017Review
- New insights into vestibular-saccade interaction based on covert corrective saccades in patients with unilateral vestibular deficits.Journal of neurophysiology · 2017Article
- The role of dentate nuclei in human oculomotor control: insights from cerebrotendinous xanthomatosis.The Journal of physiology · 2017Article
- Sensorimotor adaptation as a behavioural biomarker of early spinocerebellar ataxia type 6.Scientific reports · 2017Article
- Article
- Visual Space Constructed by Saccade Motor Maps.Frontiers in human neuroscience · 2016Review
- Oculomotor Adaptation Elicited By Intra-Saccadic Visual Stimulation: Time-Course of Efficient Visual Target Perturbation.Frontiers in human neuroscience · 2016Article
- Adaptation and adaptation transfer characteristics of five different saccade types in the monkey.Journal of neurophysiology · 2015Article
- Reply: A single session of cerebellar theta burst stimulation does not alter writing performance in writer's cramp.Brain : a journal of neurology · 2015Article
- The role of the posterior cerebellum in saccadic adaptation: a transcranial direct current stimulation study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders.Frontiers in neuroscience · 2015Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum is a key area for movement control and sensory-motor plasticity. Its medial part is considered as the exclusive cerebellar center controlling the accuracy and adaptive calibration of saccadic eye movements. However, the contribution of other zones situated in its lateral part is unknown. We addressed this question in healthy adult volunteers by using magnetic resonance imaging (MRI)-guided transcranial magnetic stimulation (TMS). The double-step target paradigm was used to adaptively lengthen or shorten saccades. TMS pulses over the right hemisphere of the cerebellum were delivered at 0, 30, or 60 ms after saccade detection in separate recording sessions. The effects on saccadic adaptation were assessed relative to a fourth session where TMS was applied to Vertex as a control site. First, TMS applied upon saccade detection before the adaptation phase reduced saccade accuracy. Second, TMS applied during the adaptation phase had a dual effect on saccadic plasticity: adaptation after-effects revealed a potentiation of the adaptive lengthening and a depression of the adaptive shortening of saccades. For the first time, we demonstrate that TMS on lateral cerebellum can influence plasticity mechanisms underlying motor performance. These findings also provide the first evidence that the human cerebellar hemispheres are involved in the control of saccade accuracy and in saccadic adaptation, with possibly different neuronal populations concerned in adaptive lengthening and shortening. Overall, these results require a reappraisal of current models of cerebellar contribution to oculomotor plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.