Evidence map›Paper›PMID 21692138›Full record

ArticleJournal of magnetic resonance imaging : JMRI2011

Initial results on development and application of statistical atlas of femoral cartilage in osteoarthritis to determine sex differences in structure: data from the Osteoarthritis Initiative.

Hussain Z Tameem, Siamak Ardekani, Leanne Seeger, Paul Thompson, Usha S Sinha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Are there gender-specific differences in hip and knee cartilage composition and degeneration? A systematic literature review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
    Pooled it
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hussain Z TameemBiomedical Engineering Department, University of California, Los Angeles, California, USA.
Siamak Ardekani
Leanne Seeger
Paul Thompson
Usha S Sinha

Funding

UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRILL, JOSHUA · 1999 to 2014
$25.9M
Amyloid Imaging, VMCI, and Analysis for ADNIRC2AG036535 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI WEINER, MICHAEL W · 2009 to 2010
$23.8M
YALE CENTER FOR THE: LEARNING &ATTENTIONP41RR013642 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GEE, JAMES C · 1998 to 2011
$21.9M
HARDI Mapping of Disease Effects on the BrainR01EB008432 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2009 to 2012
$2.6M
Genetic influences on the brain: A twin imaging studyR01HD050735 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI WRIGHT, MARGARET JANE · 2007 to 2011
$2.6M
A Context-Sensitive Teleconsultation InfrastructureR01EB002247 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINHA, USHA · 2003 to 2007
$2.0M
A Multidimensional Alzheimer's Disease Brain AtlasR01EB008281 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2007 to 2010
$1.4M
Computational Modeling of High-Field MR ImagesR01EB007813 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2007 to 2010
$1.3M
DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
–
CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
–
NCRR NIH HHS P41 RR013642NCRR NIH HHS RR013642NIAMS NIH HHS N01-AR-2-2258NIAMS NIH HHS N01-AR-2-2259NIAMS NIH HHS N01-AR-2-2260NIAMS NIH HHS N01-AR-2-2261NIAMS NIH HHS N01-AR-2-2262NIA NIH HHS AG016570NIA NIH HHS AG036535NIA NIH HHS P50 AG016570NIA NIH HHS RC2 AG036535NIBIB NIH HHS EB007813NIBIB NIH HHS EB008281NIBIB NIH HHS EB008432NIBIB NIH HHS R01 EB002247NIBIB NIH HHS R01 EB007813NIBIB NIH HHS R01 EB008281NIBIB NIH HHS R01 EB008432NICHD NIH HHS HD050735NICHD NIH HHS R01 HD050735
6 · The paper itself

Abstract

purposeTo create an average atlas of knee femoral cartilage morphology, to apply the atlas for quantitative assessment of osteoarthritis (OA), and to study localized sex differences. MATERIALS AND

methodsHigh-resolution 3D magnetic resonance imaging (MRI) data of the knee cartilage collected at 3 T as part of the Osteoarthritis Initiative (OAI) were used. An atlas was created based on images from 30 male Caucasian high-risk subjects with no symptomatic OA at baseline. A female cohort of age- and disease-matched Caucasian subjects was also selected from the OAI database. The Jacobian determinant was calculated from the deformation vector fields that nonlinearly registered each subject to the atlas. Statistical analysis based on the general linear model was used to test for regions of significant differences in the Jacobian values between the two cohorts.

resultsThe average Jacobian was larger in women (1.2 ± 0.078) than in men (1.08 ± 0.097), showing that after global scaling to the male template, the female cartilage was thicker in most regions. Regions showing significant structural differences include the medial weight bearing region, the trochlear (femoral) side of the patellofemoral compartment, and the lateral posterior condyle.

conclusionSex-based differences in cartilage structure were localized using tensor based morphometry in a cohort of high-risk subjects.

Indexed as

AgedCartilageCase-Control StudiesCohort StudiesFemaleFemurHumansMaleMiddle AgedModels, StatisticalOsteoarthritisPrincipal Component AnalysisRiskSex Characteristics

Identifiers

PMID21692138
PMCPMC3142327

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.