ArticleJournal of autism and developmental disorders2012
Brief report: the dopamine-3-receptor gene (DRD3) is associated with specific repetitive behavior in autism spectrum disorder (ASD).
Article in Journal of autism and developmental disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Biopsychological correlates of repetitive and restricted behaviors in autism spectrum disorders.Brain and behavior · 2021Pooled it
- Prenatal risk factors for Tourette Syndrome: a systematic review.BMC pregnancy and childbirth · 2014Pooled it
- Specific Reduction of Dopaminergic Fiber Input to Ventrobasal Forebrain Targets in Neonatal Mice Following Prenatal Exposure to Valproate.Biomedicines · 2026Article
- Brain receptor dynamics in early and adult life stress: Gateways to maladaptive coping strategies.Neurobiology of stress · 2025Review
- Comprehensive analysis of gut microbiota and fecal metabolites in patients with autism spectrum disorder.Frontiers in microbiology · 2025Article
- Impact of GABA and nutritional supplements on neurochemical biomarkers in autism: a PPA rodent model study.Frontiers in molecular neuroscience · 2025Article
- The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism.European journal of clinical pharmacology · 2024Article
- Gestational VPA exposure reduces the density of juxtapositions between TH+ axons and calretinin or calbindin expressing cells in the ventrobasal forebrain of neonatal mice.Frontiers in neuroanatomy · 2024Article
- Cariprazine in Pediatric Patients with Autism Spectrum Disorder: Results of a Pharmacokinetic, Safety and Tolerability Study.Journal of child and adolescent psychopharmacology · 2023Article
- Bibliometric Analysis of Research Themes and Trends of the Co-Occurrence of Autism and ADHD.Neuropsychiatric disease and treatment · 2023Review
- The cortico-striatal circuitry in autism-spectrum disorders: a balancing act.Frontiers in cellular neuroscience · 2023Review
- Early cellular and synaptic changes in dopaminoceptive forebrain regions of juvenile mice following gestational exposure to valproate.Frontiers in neuroanatomy · 2023Article
- Simultaneous Antagonism at H3R/D2R/D3R Reduces Autism-like Self-Grooming and Aggressive Behaviors by Mitigating MAPK Activation in Mice.International journal of molecular sciences · 2022Article
- Descriptive Longitudinal Analysis of Stereotypy and Corresponding Changes in Psychotropic Medication.Developmental neurorehabilitation · 2022Article
- Research Progress on the Role of Vitamin D in Autism Spectrum Disorder.Frontiers in behavioral neuroscience · 2022Review
- Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A Review.Frontiers in neuroscience · 2022Review
- Catecholaminergic and cholinergic neuromodulation in autism spectrum disorder: A comparison to attention-deficit hyperactivity disorder.Frontiers in neuroscience · 2022Review
- DNA methylome perturbations: an epigenetic basis for the emergingly heritable neurodevelopmental abnormalities associated with maternal smoking and maternal nicotine exposure†.Biology of reproduction · 2021Review
- Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models.Frontiers in neural circuits · 2021Review
- Zinc and Copper Brain Levels and Expression of Neurotransmitter Receptors in Two Rat ASD Models.Frontiers in molecular neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor "insistence on sameness" (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.