ArticleHuman genetics2011
Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD.
Article in Human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis.Molecular psychiatry · 2018Pooled it
- Genome-wide association study of obsessive-compulsive disorder.Molecular psychiatry · 2013Pooled it
- Rare protein-disrupting variants inmedRxiv : the preprint server for health sciences · 2026Article
- Neurocognitive Endophenotypes of OCD.Current topics in behavioral neurosciences · 2021Article
- Nordic OCD & Related Disorders Consortium: Rationale, design, and methods.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Article
- Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice.Physiology & behavior · 2017Article
- Neuropsychological and dimensional behavioral trait profiles in Costa Rican ADHD sib pairs: Potential intermediate phenotypes for genetic studies.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Article
- The neurobiological link between OCD and ADHD.Attention deficit and hyperactivity disorders · 2014Review
- Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective.Nature reviews. Neuroscience · 2014Review
- An inherited small microdeletion at 15q13.3 in a patient with early-onset obsessive-compulsive disorder.PloS one · 2014Article
- Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.PLoS genetics · 2013Article
- Association between SLC1A1 gene and early-onset OCD in the Han Chinese population: a case-control study.Journal of molecular neuroscience : MN · 2013Article
- Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36.Biological psychiatry · 2012Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Obsessive compulsive disorder (OCD) has a complex etiology that encompasses both genetic and environmental factors. However, to date, despite the identification of several promising candidate genes and linkage regions, the genetic causes of OCD are largely unknown. The objective of this study was to conduct linkage studies of childhood-onset OCD, which is thought to have the strongest genetic etiology, in several OCD-affected families from the genetically isolated population of the Central Valley of Costa Rica (CVCR). The authors used parametric and non-parametric approaches to conduct genome-wide linkage analyses using 5,786 single nucleotide repeat polymorphisms (SNPs) in three CVCR families with multiple childhood-onset OCD-affected individuals. We identified areas of suggestive linkage (LOD score ≥ 2) on chromosomes 1p21, 15q14, 16q24, and 17p12. The strongest evidence for linkage was on chromosome 15q14 (LOD = 3.13), identified using parametric linkage analysis with a recessive model, and overlapping a region identified in a prior linkage study using a Caucasian population. Each CVCR family had a haplotype that co-segregated with OCD across a ~7 Mbp interval within this region, which contains 18 identified brain expressed genes, several of which are potentially relevant to OCD. Exonic sequencing of the strongest candidate gene in this region, the ryanodine receptor 3 (RYR3), identified several genetic variants of potential interest, although none co-segregated with OCD in all three families. These findings provide evidence that chromosome 15q14 is linked to OCD in families from the CVCR, and supports previous findings to suggest that this region may contain one or more OCD susceptibility loci.
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