ArticleBrain tumor pathology2011
Expression of stem cell marker and receptor kinase genes in glioblastoma tissue quantified by real-time RT-PCR.
Article in Brain tumor pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Meta-Analysis and Experimental Validation Identified FREM2 and SPRY1 as New Glioblastoma Marker Candidates.International journal of molecular sciences · 2018Pooled it
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- Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response.Cancers · 2018Article
- MELK as a potential target to control cell proliferation in triple-negative breast cancer MDA-MB-231 cells.Oncology letters · 2018Article
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- Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature.Neuro-oncology · 2016Article
- Malignant clinical features of anaplastic gliomas without IDH mutation.Neuro-oncology · 2015Article
- Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway.Molecular cancer · 2014Article
- Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms.Journal of cellular and molecular medicine · 2013Review
- The impact of age on oncogenic potential: tumor-initiating cells and the brain microenvironment.Aging cell · 2013Review
- NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200.Neuro-oncology · 2013Article
- Associations between microRNA expression and mesenchymal marker gene expression in glioblastoma.Neuro-oncology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma is dependent on a specific signaling pathway to maintain its tumor phenotype. The receptor tyrosine kinase (RTK) family mediates the multiple oncogenic growth factor receptor signaling and contributes to the pathogenesis of glioblastoma. Recently, many studies have shown that the expression of stem cell marker in glioblastoma tissue has prognostic significance, which indicates that the quantification of stem cell markers and RTK genes yields biological information about glioblastoma. In this study, we quantified RNA expression levels of stem cell markers [CD133, Nestin, BMI-1, maternal embryonic leucine zipper kinase (MELK), and Notch1-4] as well as RTKs (EGFR, ErbB4, VEGFR1-3, FGFR1, -2, PDGFRΑ, and PDGFRΒ) in 42 clinical samples of glioblastoma by the real-time RT-PCR method. We demonstrated that the expression of MELK is exclusively upregulated in glioblastoma tissue. Notch receptor expression is moderately upregulated and is correlated with that of VEGFR2, VEGFR3, and PDGFRβ. Unsupervised clustering identified one unique sample group that showed high expression of most of the genes analyzed. Our results suggest that quantification of these stem cell markers and RTK genes can stratify patients based on the expression profile, which might provide insight into the glioma biology in each cluster.
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