ArticleCell research2011
mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C. elegans.
Article in Cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Exogenous expression of a histone H3.3 isoform causes extranuclear divisions in thebioRxiv : the preprint server for biology · 2025Article
- EBAX-1/ZSWIM8 destabilizes miRNAs, resulting in transgenerational inheritance of a predatory trait.Science advances · 2025Article
- Widespread destabilization ofRNA (New York, N.Y.) · 2024Article
- The developmentally timed decay of an essential microRNA family is seed-sequence dependent.Cell reports · 2022Article
- Small RNAs couple embryonic developmental programs to gut microbes.Science advances · 2022Article
- microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development.Nucleic acids research · 2021Article
- The Potential Role of Circulating MicroRNAs in Male Rat Infertility Treated withEvidence-based complementary and alternative medicine : eCAM · 2021Article
- In vivo CRISPR screening for phenotypic targets of theGenes & development · 2020Article
- MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways.Cell death and differentiation · 2019Article
- Prolonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target MAB-3 in nematode Caenorhabditis elegans.Scientific reports · 2019Article
- RNA interference may result in unexpected phenotypes in Caenorhabditis elegans.Nucleic acids research · 2019Article
- TheG3 (Bethesda, Md.) · 2019Article
- MicroRNA-424/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway.Journal of ovarian research · 2018Article
- A microRNA family exerts maternal control on sex determination inGenes & development · 2017Article
- miRNAs cooperate in apoptosis regulation duringGenes & development · 2017Article
- Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegans.Genetics · 2016Article
- microRNA regulation of the embryonic hypoxic response in Caenorhabditis elegans.Scientific reports · 2015Article
- Article
- The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2014Article
- RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans.Open biology · 2013Article
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Authors and funding
9 authors.
Funding
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Abstract
MicroRNA (miRNA) regulates gene expression in many cellular events, yet functions of only a few miRNAs are known in C. elegans. We analyzed the function of mir-35-41 unique to the worm, and show here that mir-35 regulates the G1/S transition of intestinal cells and germ cell proliferation. Loss of mir-35 leads to a decrease of nuclei numbers in intestine and distal mitotic gonad, while re-introduction of mir-35 rescues the mutant phenotypes. Genetic analysis indicates that mir-35 may act through Rb/E2F and SCF pathways. Further bioinformatic and functional analyses demonstrate that mir-35 targets evolutionally conserved lin-23 and gld-1. Together, our study reveals a novel function of mir-35 family in cell division regulation.
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