Evidence map›Paper›PMID 21691215›Full record

ReviewThe Journal of head trauma rehabilitation

Noninvasive brain stimulation in traumatic brain injury.

Asli Demirtas-Tatlidede, Andrew M Vahabzadeh-Hagh, Montserrat Bernabeu, Jose M Tormos, Alvaro Pascual-Leone

4 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in The Journal of head trauma rehabilitation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 65 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04760899 naactive not recruitingnot on this map

Bilateral Cerebellar Transcranial Direct Current Stimulation (tDCS) for the Treatment of Sports-Related Post-Concussion Syndrome (SRPCS)

TypeinterventionalSponsorUniversity of IowaRan2021 to 2027Enrolled31ConditionsPost-Concussion SyndromeArmsTranscranial Direct Current Stimulation
NCT05863494 naunknown statusnot on this map

Toward Personalized Treatment of Chronic Pain Using Transcranial Direct Current Stimulation Paired With Deep Learning

TypeinterventionalSponsorUniversity of ArizonaRan2023 to 2023Enrolled40ConditionsChronic PainArmsTranscranial Direct Current Stimulation (tDCS), Transcranial Direct Current Stimulation (tDCS) sham
NCT06228872 naunknown statusnot on this map

Direct Current Transcranial Stimulation as Cognitive Rehabilitation Therapy in Post-Traumatic Brain Injury Patients.

TypeinterventionalSponsorMutual de Seguridad Hospital ClinicoRan2024 to 2025Enrolled38ConditionsTraumatic Brain Injury, Cognitive ImpairmentArmsCognitive Computerized Training (CCT) plus Anodic transcranial Direct Current Stimulation (tDCS), Cognitive Computerized Training (CCT) plus sham transcranial Direct Current Stimulation (tDCS)
NCT06775145 nanot yet recruitingnot on this map

Therapeutic Effect of Neuromodulation on Anxiety Disorders by High-Definition Transcranial Electrical Stimulation

TypeinterventionalSponsorNational Taiwan University HospitalRan2025 to 2025Enrolled100ConditionsGeneralized Anxiety Disorder (GAD)ArmsHD-R_cDC+cTBS & sham-L_aDC+iTBS, sham-R_cDC+cTBS & HD-L_aDC+iTBS, HD-R_cDC+cTBS & HD-L_aDC+iTBS, sham-R_cDC+cTBS & sham-L_aDC+iTBS
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 154 citations in OpenAlex.

  1. Efficacy of rTMS combined with cognitive training in TBI with cognition disorder: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
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  14. Targeting Prefrontal Cortex Dysfunction in Pain.The Journal of pharmacology and experimental therapeutics · 2024
    Review
  15. Therapeutic management of ischemic stroke.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Asli Demirtas-TatlidedeBerenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Andrew M Vahabzadeh-Hagh
Montserrat Bernabeu
Jose M Tormos
Alvaro Pascual-Leone
Berenson Allen Center for Noninvasive Brain Stimulation · US

Funding

Study and Modulation of Brian PlasticityK24RR018875 · NCRR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2004 to 2008
$602k
NCRR NIH HHS K24 RR018875
6 · The paper itself

Abstract

objectiveTo review novel techniques of noninvasive brain stimulation (NBS), which may have value in assessment and treatment of traumatic brain injury (TBI).

methodsReview of the following techniques: transcranial magnetic stimulation, transcranial direct current stimulation, low-level laser therapy, and transcranial Doppler sonography. Furthermore, we provide a brief overview of TMS studies to date. MAIN

findingsWe describe the rationale for the use of these techniques in TBI, discuss their possible mechanisms of action, and raise a number of considerations relevant to translation of these methods to clinical use. Depending on the stimulation parameters, NBS may enable suppression of the acute glutamatergic hyperexcitability following TBI and/or counter the excessive GABAergic effects in the subacute stage. In the chronic stage, brain stimulation coupled to rehabilitation may enhance behavioral recovery, learning of new skills, and cortical plasticity. Correlative animal models and comprehensive safety trials seem critical to establish the use of these modalities in TBI.

conclusionsDifferent forms of NBS techniques harbor the promise of diagnostic and therapeutic utility, particularly to guide processes of cortical reorganization and enable functional restoration in TBI. Future lines of safety research and well-designed clinical trials in TBI are warranted to determine the capability of NBS to promote recovery and minimize disability.

Indexed as

Electric Stimulation TherapyTranscranial Magnetic StimulationAnimalsBrainBrain InjuriesBrain Injury, ChronicBrain MappingCerebral CortexCombined Modality TherapyDisease Models, AnimalEvoked Potentials, MotorHumansMagnetic Resonance ImagingNerve RegenerationNeuronal PlasticityNeurotransmitter AgentsNeurotransmitter Agents

Identifiers

PMID21691215
PMCPMC3342413
OpenAlexW2117293864

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.