ReviewProceedings of the National Academy of Sciences of the United States of America2011
Pathology from evolutionary conflict, with a theory of X chromosome versus autosome conflict over sexually antagonistic traits.
Review in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Analysis of the impact of gene evolution on reproductive effects reveals prevalent sexual and germline-soma conflicts.Nature ecology & evolution · 2026Article
- Brinkmanship in intragenomic conflict.Proceedings. Biological sciences · 2025Article
- Polygenic response of sex chromosomes to sexual antagonism.Evolution; international journal of organic evolution · 2024Article
- Nausea, vomiting and conflict in pregnancy: The adaptive significance of Growth-Differentiation Factor 15.Evolution, medicine, and public health · 2024Article
- Disease from opposing forces in regulatory control.Evolution, medicine, and public health · 2023Article
- Genetic conflicts and the case for licensed anthropomorphizing.Behavioral ecology and sociobiology · 2022Review
- Experimental evolution reveals sex-specific dominance for surviving bacterial infection in laboratory populations ofEvolution letters · 2021Article
- Sexual Antagonism, Temporally Fluctuating Selection, and Variable Dominance Affect a Regulatory Polymorphism in Drosophila melanogaster.Molecular biology and evolution · 2021Article
- The influence of evolutionary history on human health and disease.Nature reviews. Genetics · 2021Review
- Variable dosage compensation is associated with female consequences of an X-linked, male-beneficial mutation.Proceedings. Biological sciences · 2021Article
- A gene's-eye view of sexual antagonism.Proceedings. Biological sciences · 2020Article
- Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health.International journal of epidemiology · 2020Article
- Evolution of negative immune regulators.PLoS pathogens · 2019Article
- Why and How Imprinted Genes Drive Fetal Programming.Frontiers in endocrinology · 2019Article
- Sexual selection and cancer biology.Oncotarget · 2015Article
- Genomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone.Evolutionary applications · 2015Review
- Conflict over condition-dependent sex allocation can lead to mixed sex-determination systems.Evolution; international journal of organic evolution · 2014Article
- Review
- First principles of Hamiltonian medicine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- The insectan apes.Human nature (Hawthorne, N.Y.) · 2014Article
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2 authors.
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Abstract
Evolutionary conflicts cause opponents to push increasingly hard and in opposite directions on the regulation of traits. One can see only the intermediate outcome from the balance of the exaggerated and opposed forces. Intermediate expression hides the underlying conflict, potentially misleading one to conclude that trait regulation is designed to achieve efficient and robust expression, rather than arising by the precarious resolution of conflict. Perturbation often reveals the underlying nature of evolutionary conflict. Upon mutation or knockout of one side in the conflict, the other previously hidden and exaggerated push on the trait may cause extreme, pathological expression. In this regard, pathology reveals hidden evolutionary design. We first review several evolutionary conflicts between males and females, including conflicts over mating, fertilization, and the growth rate of offspring. Perturbations of these conflicts lead to infertility, misregulated growth, cancer, behavioral abnormalities, and psychiatric diseases. We then turn to antagonism between the sexes over traits present in both males and females. For many traits, the different sexes favor different phenotypic values, and constraints prevent completely distinct expression in the sexes. In this case of sexual antagonism, we present a theory of conflict between X-linked genes and autosomal genes. We suggest that dysregulation of the exaggerated conflicting forces between the X chromosome and the autosomes may be associated with various pathologies caused by extreme expression along the male-female axis. Rapid evolution of conflicting X-linked and autosomal genes may cause divergence between populations and speciation.
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