Evidence map›Paper›PMID 21690347›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2011

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform.

Che-Ming J Hu, Li Zhang, Santosh Aryal, Connie Cheung, Ronnie H Fang, Liangfang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 933 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
933citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

933 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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873 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Che-Ming J HuDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Li Zhang
Santosh Aryal
Connie Cheung
Ronnie H Fang
Liangfang Zhang

Funding

Tumor Therapy/Annihilation Using a Smart NanoPlatform (SNaP)U54CA119335 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESENER, SADIK · 2005 to 2010
$21.2M
NCI NIH HHS U54 CA119335NCI NIH HHS U54CA119335
6 · The paper itself

Abstract

Efforts to extend nanoparticle residence time in vivo have inspired many strategies in particle surface modifications to bypass macrophage uptake and systemic clearance. Here we report a top-down biomimetic approach in particle functionalization by coating biodegradable polymeric nanoparticles with natural erythrocyte membranes, including both membrane lipids and associated membrane proteins for long-circulating cargo delivery. The structure, size and surface zeta potential, and protein contents of the erythrocyte membrane-coated nanoparticles were verified using transmission electron microscopy, dynamic light scattering, and gel electrophoresis, respectively. Mice injections with fluorophore-loaded nanoparticles revealed superior circulation half-life by the erythrocyte-mimicking nanoparticles as compared to control particles coated with the state-of-the-art synthetic stealth materials. Biodistribution study revealed significant particle retention in the blood 72 h following the particle injection. The translocation of natural cellular membranes, their associated proteins, and the corresponding functionalities to the surface of synthetic particles represents a unique approach in nanoparticle functionalization.

Indexed as

Drug Delivery SystemsAnimalsBiomimetic MaterialsErythrocyte MembraneFluorescent DyesLactic AcidMaleMiceMice, Inbred ICRNanoparticlesParticle SizePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerTissue DistributionFluorescent DyesLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymer

Identifiers

PMID21690347
PMCPMC3131364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.