ArticleJournal of immunology (Baltimore, Md. : 1950)2011
A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 33 citations in OpenAlex.
- Rag1-based time-stamp tracing of T-cell developmental origins.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Dysfunctional CD4 T cells in an oncovirus-specific TCR-transgenic in vivo model.Nature communications · 2025Article
- High Antigenicity for TCancer science · 2025Article
- T-reg transcriptomic signatures identify response to check-point inhibitors.Scientific reports · 2024Article
- Systems immunology of regulatory T cells: can one circuit explain it all?Trends in immunology · 2023Review
- Cross-Activation of Regulatory T Cells by Self Antigens Limits Self-Reactive and Activated CD8International journal of molecular sciences · 2023Article
- Functional Diversities of Regulatory T Cells in the Context of Cancer Immunotherapy.Frontiers in immunology · 2022Review
- Dormant pathogenic CD4Nature communications · 2019Article
- High self-reactivity drives T-bet and potentiates Treg function in tissue-specific autoimmunity.JCI insight · 2018Article
- TGF-β1/Smad2/3/Foxp3 signaling is required for chronic stress-induced immune suppression.Journal of neuroimmunology · 2018Article
- Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype.Scientific reports · 2017Article
- Tubulointerstitial nephritis as adverse effect of programmed cell death 1 inhibitor, nivolumab, showed distinct histological findings.CEN case reports · 2017Article
- Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity.The Journal of experimental medicine · 2017Article
- Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis.Frontiers in immunology · 2017Review
- Affinity for self antigen selects Treg cells with distinct functional properties.Nature immunology · 2016Article
- Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus.Nature communications · 2016Article
- Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective.Immunology and cell biology · 2016Article
- Controlling the fire--tissue-specific mechanisms of effector regulatory T-cell homing.Immunology and cell biology · 2015Review
- Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation.Immunological reviews · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Although Foxp3(+) regulatory T cells (Tregs) are thought to express autoreactive TCRs, it is not clear how individual TCRs influence Treg development, phenotype, and function in vivo. We have generated TCR transgenic mice (termed SFZ70 mice) using Tcra and Tcrb genes cloned from an autoreactive CD4(+) T cell isolated from a Treg-deficient scurfy mouse. The SFZ70 TCR recognizes a cutaneous autoantigen and drives development of both conventional CD4(+) Foxp3(-) T cells (T(conv)) and Foxp3(+) Tregs. SFZ70 Tregs display an activated phenotype evidenced by robust proliferation and expression of skin-homing molecules such as CD103 and P-selectin ligand. Analysis of Foxp3-deficient SFZ70 mice demonstrates that Tregs inhibit T(conv) cell expression of tissue-homing receptors and their production of proinflammatory cytokines. In addition, Treg suppression of SFZ70 T(conv) cells can be overcome by nonspecific activation of APCs. These results provide new insights into the differentiation and function of tissue-specific Tregs in vivo and provide a tractable system for analyzing the molecular requirements of Treg-mediated tolerance toward a cutaneous autoantigen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.