ArticleMolecular and cellular biology2011
Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Effect of Bovine Follicular Fluid Small Extracellular Vesicles Isolated by Ultracentrifugation and Chromatography on In Vitro Oocyte Maturation and Embryo Development.International journal of molecular sciences · 2025Article
- Genome-wide landscape of genetic diversity, runs of homozygosity, and runs of heterozygosity in five Alpine and Mediterranean goat breeds.Journal of animal science and biotechnology · 2025Article
- Non-cell-autonomous regulation of germline proteostasis by insulin/IGF-1 signaling-induced dietary peptide uptake via PEPT-1.The EMBO journal · 2024Article
- The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity.Nature cell biology · 2024Article
- Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling.Biochemical Society transactions · 2023Article
- HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia.Nature communications · 2022Article
- Protecting the future: balancing proteostasis for reproduction.Trends in cell biology · 2022Review
- Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.Cell stem cell · 2021Article
- Insulin/IGF-1 signaling and heat stress differentially regulate HSF1 activities in germline development.Cell reports · 2021Article
- The Multifaceted Role of HSF1 in Pathophysiology: Focus on Its Interplay with TG2.International journal of molecular sciences · 2021Review
- Genetic response to low‑intensity ultrasound on mouse ST2 bone marrow stromal cells.Molecular medicine reports · 2021Article
- Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health.Frontiers in cell and developmental biology · 2021Review
- Cellular quality control during gametogenesis.Experimental cell research · 2020Review
- HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes.International journal of molecular sciences · 2019Article
- High-throughput Exploration of the Network Dependent on AKT1 in Mouse Ovarian Granulosa Cells.Molecular & cellular proteomics : MCP · 2019Article
- High Temporal-Resolution Transcriptome Landscape of Early Maize Seed Development.The Plant cell · 2019Article
- Tailoring of Proteostasis Networks with Heat Shock Factors.Cold Spring Harbor perspectives in biology · 2019Review
- Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia.Nature medicine · 2018Article
- Roles of heat shock factor 1 beyond the heat shock response.Cellular and molecular life sciences : CMLS · 2018Review
- Rethinking HSF1 in Stress, Development, and Organismal Health.Trends in cell biology · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock factor 1 (HSF1), while recognized as the major regulator of the heat shock transcriptional response, also exerts important functions during mammalian embryonic development and gametogenesis. In particular, HSF1 is required for oocyte maturation, the adult phase of meiosis preceding fertilization. To identify HSF1 target genes implicated in this process, comparative transcriptomic analyses were performed with wild-type and HSF-deficient oocytes. This revealed a network of meiotic genes involved in cohesin and synaptonemal complex (SC) structures, DNA recombination, and the spindle assembly checkpoint (SAC). All of them were found to be regulated by HSF1 not only during adult but also in embryonic phases of female meiosis. Additional investigations showed that SC, recombination nodules, and DNA repair were affected in Hsf1(-/-) oocytes during prenatal meiotic prophase I. However, targeting Hsf1 deletion to postnatal oocytes (using Zp3 Cre; Hsf1(loxP/loxP)) did not fully rescue the chromosomal anomalies identified during meiotic maturation, which possibly caused a persistent SAC activation. This would explain the metaphase I arrest previously described in HSF1-deficient oocytes since SAC inhibition circumvented this block. This work provides new insights into meiotic gene regulation and points out potential links between cellular stress and the meiotic anomalies frequently observed in humans.
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