ArticleAntimicrobial agents and chemotherapy2011
Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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119 citing papers in PubMed.
- Persistence of azole-resistantmSphere · 2026Article
- Prevalence of cyp51A variants in a US collection of Aspergillus fumigatus clinical isolates and comparative analysis of their contribution to triazole antifungal resistance.The Journal of antimicrobial chemotherapy · 2026Article
- Global epidemiology of azole resistance inJAC-antimicrobial resistance · 2026Review
- Novel Genetic Diversity and Geographic Structures ofMicroorganisms · 2026Article
- Unravelling azole resistance in fungal pathogens: molecular mechanisms, diagnostic challenges, and therapeutic strategies.World journal of microbiology & biotechnology · 2025Review
- Development and validation of next-generation sequencing-based clinical test for triazole resistance prediction inJournal of clinical microbiology · 2025Article
- Comprehensive Review of Environmental Surveillance for Azole-ResistantJournal of fungi (Basel, Switzerland) · 2025Review
- Molecular Identification ofInfection and drug resistance · 2025Article
- Antifungal activity of ETD151 against azole-susceptible and -resistantCurrent research in microbial sciences · 2025Article
- Azole Resistance in Veterinary Clinical Aspergillus fumigatus Isolates in the Netherlands.Mycopathologia · 2024Article
- cyp51A mutations, protein modeling, and efflux pump gene expression reveals multifactorial complexity towards understanding Aspergillus section Nigri azole resistance mechanism.Scientific reports · 2024Article
- Uncovering a NovelJournal of fungi (Basel, Switzerland) · 2024Article
- Aspergillus Species Causing Invasive Fungal Disease in Queensland, Australia.Mycopathologia · 2023Article
- Fungal Drug Response and Antimicrobial Resistance.Journal of fungi (Basel, Switzerland) · 2023Review
- Potency of olorofim (F901318) compared to contemporary antifungal agents against clinicalAntimicrobial agents and chemotherapy · 2023Article
- Molecular epidemiology and antifungal susceptibilities of Aspergillus species isolated from patients with invasive aspergillosis.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Analysis of Cyp51 protein sequences shows 4 major Cyp51 gene family groups across fungi.G3 (Bethesda, Md.) · 2022Article
- Acquisition of cross-azole tolerance and aneuploidy in Candida albicans strains evolved to posaconazole.G3 (Bethesda, Md.) · 2022Article
- Species Distribution and Antifungal Susceptibilities ofJournal of clinical microbiology · 2022Article
- Genetic Diversity and Azole Resistance Among Natural Aspergillus fumigatus Populations in Yunnan, China.Microbial ecology · 2022Article
59 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
We surveyed 497 isolates of Aspergillus fumigatus collected from 2008 to 2009 as part of the ARTEMIS global surveillance study for elevated MIC values to itraconazole, voriconazole, and posaconazole. Sequencing of the cyp51A gene revealed that 8/29 isolates with elevated MIC values to one or more triazoles, all originating in China, contained the TR/L98H mutation associated with resistant European isolates of A. fumigatus. This is the first time the TR/L98H mutation has been identified outside Europe.
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