ArticleThe Journal of physiology2011
Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Mechanisms of Attenuation of Pulmonary V'O2 Slow Component in Humans after Prolonged Endurance Training.PloS one · 2016Trial
- In vivo quantification of mitochondrial OThe Journal of physiology · 2026Article
- Mitochondrial efficiency in resting skeletal muscle in vivo: a novel non-invasive approach using multinuclear magnetic resonance spectroscopy in humans.The Journal of physiology · 2025Article
- Changes in muscle oxygenation and activity during cumulative isometric muscle contraction: new insight into muscle fatigue.Frontiers in physiology · 2025Article
- Methodological considerations on near-infrared spectroscopy derived muscle oxidative capacity.European journal of applied physiology · 2024Article
- Exercise metabolism and adaptation in skeletal muscle.Nature reviews. Molecular cell biology · 2023Review
- How Priming Exercise Affects Oxygen Uptake Kinetics: From Underpinning Mechanisms to Endurance Performance.Sports medicine (Auckland, N.Z.) · 2023Review
- Energy metabolism design of the striated muscle cell.Physiological reviews · 2021Review
- Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction.Acta physiologica (Oxford, England) · 2020Article
- The Functional Impact of Mitochondrial Structure Across Subcellular Scales.Frontiers in physiology · 2020Review
- MitoRACE: evaluating mitochondrial function in vivo and in single cells with subcellular resolution using multiphoton NADH autofluorescence.The Journal of physiology · 2019Article
- "Work-to-Work" exercise slows pulmonary oxygen uptake kinetics, decreases critical power, and increases W' during supine cycling.Physiological reports · 2018Article
- Oxygen availability and skeletal muscle oxidative capacity in patients with peripheral artery disease: implications from in vivo and in vitro assessments.American journal of physiology. Heart and circulatory physiology · 2018Article
- Mechanisms underlying extremely fast muscle V˙OPhysiological reports · 2018Article
- Elevated baseline work rate slows pulmonary oxygen uptake kinetics and decreases critical power during upright cycle exercise.Physiological reports · 2018Article
- Regulation of oxidative phosphorylation is different in electrically- and cortically-stimulated skeletal muscle.PloS one · 2018Article
- Dissociating external power from intramuscular exercise intensity during intermittent bilateral knee-extension in humans.The Journal of physiology · 2017Article
- Blood lactate accumulation decreases during the slow component of oxygen uptake without a decrease in muscular efficiency.Pflugers Archiv : European journal of physiology · 2017Article
- Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD.Respiratory physiology & neurobiology · 2017Article
- Accuracy and precision of quantitative 31P-MRS measurements of human skeletal muscle mitochondrial function.American journal of physiology. Endocrinology and metabolism · 2016Article
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
Abstract
Fast kinetics of muscle oxygen consumption (VO2) is characteristic of effective physiological systems integration. The mechanism of VO2 kinetic control in vivo is equivocal as measurements are complicated by the twin difficulties of making high-frequency direct measurements of VO2 and intramuscular metabolites, and in attaining high [ADP]; complexities that can be overcome utilising highly aerobic canine muscle for the investigation of the transition from rest to contractions at maximal VO2. Isometric tetanic contractions of the gastrocnemius complex of six anaesthetised, ventilated dogs were elicited via sciatic nerve stimulation (50 Hz; 200 ms duration; 1 contraction s(−1)). Muscle VO2 and lactate efflux were determined from direct Fick measurements. Muscle biopsies were taken at rest and every ∼10 s during the transient and analysed for [phosphates], [lactate] and pH. The temporal VO2 vs. [PCr] and [ADP] relationships were not well fitted by linear or classical hyperbolic models (respectively), due to the high sensitivity of VO2 to metabolic perturbations early in the transient. The time course of this apparent sensitisation was closely aligned to that of ATP turnover, which was lower in the first ∼25 s of contractions compared to the steady state. These findings provide the first direct measurements of skeletal muscle VO2 and [PCr] in the non-steady state, and suggest that simple phosphate feedback models (which are adequate for steady-state observations in vitro) are not sufficient to explain the dynamic control of VO2 in situ. Rather an allosteric or 'parallel activation' mechanism of energy consuming and producing processes is required to explain the kinetic control of VO2 in mammalian skeletal muscle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.