ArticleThe American journal of pathology2011
An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Screening and identification of biomarkers in tumor-educated platelets for non-small cell lung cancer.BMC cancer · 2026Article
- Stearoyl-CoA Desaturase-1 Drives Tumor Growth by Interacting With Histone Deacetylase-2 and Deacetylating Nucleophosmin-1.MedComm · 2026Article
- Loss of NPM2 expression is a potential immunohistochemical marker for malignant peritoneal mesothelioma: a single-center study of 92 cases.World journal of surgical oncology · 2022Article
- Characterizing the Relapse Potential in Different Luminal Subtypes of Breast Cancers with Functional Proteomics.International journal of molecular sciences · 2020Article
- A three layered histone epigenetics in breast cancer metastasis.Cell & bioscience · 2020Review
- Review
- Phosphoproteome Profiling Reveals Multifunctional Protein NPM1 as part of the Irradiation Response of Tumor Cells.Translational oncology · 2019Article
- Knockdown of nucleophosmin 1 suppresses proliferation of triple-negative breast cancer cells through activating CDH1/Skp2/p27kip1 pathway.Cancer management and research · 2019Article
- Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families.Breast cancer research and treatment · 2017Article
- Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1.Nucleic acids research · 2017Article
- Nucleophosmin: from structure and function to disease development.BMC molecular biology · 2016Review
- NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape.Scientific reports · 2015Article
- Humoral autoimmune response to nucleophosmin in the immunodiagnosis of hepatocellular carcinoma.Oncology reports · 2015Article
- Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents.Seminars in cancer biology · 2014Review
- Deregulated expression of Nucleophosmin 1 in gastric cancer and its clinicopathological implications.BMC gastroenterology · 2014Article
- Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling.Cancer cell international · 2014Article
- Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.Breast cancer research : BCR · 2012Article
- Nuclear export of proteins and drug resistance in cancer.Biochemical pharmacology · 2012Review
- Regulation of subcellular distribution and oncogenic potential of nucleophosmin by plakoglobin.Oncogenesis · 2012Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleophosmin (NPM) is a multifunctional protein involved in a complex network of interactions. The role of NPM in oncogenesis is controversial. The NPM gene (NPM1) is mutated or rearranged in a number of hematological disorders, but such changes have not been detected in solid cancers. However, experiments with cultured NPM-null cells and with mice carrying a single inactivated NPM allele indicate a tumor suppressor function for NPM. To resolve the role of NPM in solid cancers, we examined its expression and localization in histologically normal breast tissue and a large array of human breast carcinoma samples (n = 1160), and also evaluated its association with clinicopathological variables and patient survival. The intensity and localization (nucleolar, nuclear, cytoplasmic) of NPM varied across clinical samples. No mutations explaining the differences were found, but the present findings indicate that expression levels of NPM affected its localization. Our study also revealed a novel granular staining pattern for NPM, which was an independent prognostic factor of poor prognosis. In addition, reduced levels of NPM protein were associated with poor prognosis. Furthermore, luminal epithelial cells of histologically normal breast displayed high levels of NPM and overexpression of NPM in the invasive MDA-MB-231 cells abrogated their growth in soft agar. These results support a tumor suppressive role for NPM in breast cancer.
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