Evidence map›Paper›PMID 21689496›Full record

ArticleInternational MS journal2011

Epstein-Barr Virus and MS:Causality or Association?

Sk Ludwin, S Jacobson

Abstract read
In one paragraph

Article in International MS journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Evaluation of reactive Epstein-Barr Virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS).The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sk LudwinDepartment of Pathology and Molecular Medicine, Queens University, Kingston, Ontario, Canada, K7L 3N6 Tel: +1 613 533 2818 Fax: +1 613 533 2907 E-mail: ludwin@cliff.path.queensu.ca.
S Jacobson

Funding

Involvement Of Human Viruses Associated With Chronic Neurologic DiseaseZIANS002817 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI JACOBSON, STEVEN · 2009 to 2025
$26.5M
Translational studies of human viruses and chronic neurologic diseaseZIANS003040 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI JACOBSON, STEVEN · 2009 to 2025
$10.1M
Retrovirus Associated With Chronic Neurologic DiseaseZ01NS002817 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI JACOBSON, STEVEN · 1990 to 2008
$4.0M
Translational studies of human viruses and chronic neurologic disesaeZ01NS003040 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI JACOBSON, STEVEN · 2007 to 2008
$1.7M
Intramural NIH HHS Z01 NS002817Intramural NIH HHS Z01 NS003040
6 · The paper itself

Abstract

The search for the aetiology of multiple sclerosis (MS) has led to many theories over the years. It has become clear, however, that MS is complex and multifactorial, involving many interlacing mechanisms, many of which appear to be playing a role in the causation and evolution of the disease. In the large part for epidemiological reasons, an infectious aetiology has always been a prime suspect in this search. Although many agents have been examined over the years, the Epstein-Barr virus (EBV) has re-emerged as a candidate pathogen, based to a large degree on sero-epidemiological evidence, and on the knowledge of the effects this virus is capable of producing in other situations.

Indexed as

Herpesvirus 4, HumanMultiple SclerosisBiological EvolutionCommunicable DiseasesEpstein-Barr Virus InfectionsHumansInfectious Mononucleosis

Identifiers

PMID21689496
PMCPMC4996117

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.