ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2011
The role of laparoscopic staging in patients with incidental gallbladder cancer.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Transabdominal ultrasound and endoscopic ultrasound for diagnosis of gallbladder polyps.The Cochrane database of systematic reviews · 2018Pooled it
- Gallbladder cancer: expert consensus statement.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2015Guideline
- The Clinical Role of Preoperative Serum CA19-9 and Carcinoembryonic Antigen (CEA) Levels in Evaluating the Resectability of Advanced Gallbladder Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Incidental Gallbladder Cancer: A Comprehensive Review.Journal of gastrointestinal cancer · 2025Review
- Machine Learning Algorithm for Predicting Distant Metastasis of T1 and T2 Gallbladder Cancer Based on SEER Database.Bioengineering (Basel, Switzerland) · 2024Article
- Treatment Outcomes of Incidental Gallbladder Cancer - Results from a High-Volume Tertiary Care Centre in North India.Indian journal of surgical oncology · 2024Article
- Unveiling the best predictive models for early‑onset metastatic cancer: Insights and innovations (Review).Oncology reports · 2024Review
- Utility of 18-Flurodeoxyglucose Positron Emission Tomography-Computed Tomography (World journal of nuclear medicine · 2023Article
- The diagnostic value of staging laparoscopy in gallbladder cancer: a nationwide cohort study.World journal of surgical oncology · 2023Article
- Incidental gallbladder cancer: what is the prevalence and how do we perform cholecystectomy for presumably benign biliary disease?Revista do Colegio Brasileiro de Cirurgioes · 2023Observational
- Gallbladder cancer.Nature reviews. Disease primers · 2022Review
- Article
- Treatment of Resectable Gallbladder Cancer.Cancers · 2022Review
- Risk factors and prognosis of liver metastasis in gallbladder cancer patients: A SEER-based study.Frontiers in surgery · 2022Article
- Laparoscopic surgery for oncologic extended resection of T1b and T2 incidental gallbladder carcinoma at a high-volume center: a single-center experience in China.Surgical endoscopy · 2021Article
- Determinants of curative resection in incidental gallbladder carcinoma with special reference to timing of referral.Annals of hepato-biliary-pancreatic surgery · 2021Article
- Surgical management of biliary malignancy.Current problems in surgery · 2021Article
- BRAZILIAN CONSENSUS ON INCIDENTAL GALLBLADDER CARCINOMA.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2020Article
- A Novel Nomogram Predicting Distant Metastasis in T1 and T2 Gallbladder Cancer: A SEER-based Study.International journal of medical sciences · 2020Article
- A Comparison Between the Prognosis of Simultaneous and Salvage Radical Resection in Incidental Gallbladder Cancer.Cancer management and research · 2020Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of staging laparoscopy (SL) in patients with incidental gallbladder cancer (IGBC) is ill defined. This study evaluates the utility of SL with the aim of identifying variables associated with disseminated disease (DD).
methodsConsecutive patients with IGBC who underwent re-exploration between 1998 and 2009 were identified from a prospective database. The yield and accuracy of SL were calculated. Demographics, tumour- and treatment-related variables were correlated with findings of DD.
resultsOf the 136 patients submitted to re-exploration for possible definitive resection, 19 (14.0%) had DD. Staging laparoscopy was carried out in 46 (33.8%) patients, of whom 10 (21.8%) had DD (peritoneal disease [n = 6], liver metastases [n = 3], retroperitoneal disease [n = 1]). Disseminated disease was identified by SL in two patients (yield = 4.3%), whereas eight were diagnosed after conversion to laparotomy (accuracy = 20.0%). The likelihood of DD correlated closely with T-stage (T1b, n = 0; T2, n = 5 [7.0%], T3, n = 14 [26.0%]; P = 0.004). A positive margin at initial cholecystectomy (odds ratio [OR] 5.44, 95% confidence interval [CI] 1.51-24.37; P = 0.004) and tumour differentiation (OR 7.64, 95% CI 1.1-NA; P= 0.006) were independent predictors of DD on multivariate analysis. DISCUSSION: Disseminated disease is relatively uncommon in patients with IGBC and SL provides a very low yield. However, patients with poorly differentiated, T3 or positive-margin gallbladder tumours are at high risk for DD and targeting these patients may increase the yield of SL.
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