ArticleJapanese journal of cancer research : Gann1990
Induction of growth factor-receptor and metalloproteinase genes by epidermal growth factor and/or transforming growth factor-alpha in human gastric carcinoma cell line MKN-28.
Article in Japanese journal of cancer research : Gann, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Southwest Oncology Group study S0413: a phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2011Trial
- Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer.Cancer science · 2012Article
- Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha.Cancer science · 2006Article
- Cellular and molecular aspects of gastric cancer.World journal of gastroenterology · 2006Review
- Expression of Cbl linking with the epidermal growth factor receptor system is associated with tumor progression and poor prognosis of human gastric carcinoma.Virchows Archiv : an international journal of pathology · 2004Article
- Effect of 5-fluorouracil and epidermal growth factor on cell growth and dihydropyrimidine dehydrogenase regulation in human uterine cervical carcinoma SKG-IIIb cells.Cancer science · 2003Article
- Effects of sex steroids and growth factors on invasive activity and 5'-deoxy-5-fluorouridine sensitivity in ovarian adenocarcinoma OMC-3 cells.Japanese journal of cancer research : Gann · 1998Article
- In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.British journal of cancer · 1998Article
- Expression of interleukin-6 and its effect on the cell growth of gastric carcinoma cell lines.Japanese journal of cancer research : Gann · 1997Article
- Rho proteins play a critical role in cell migration during the early phase of mucosal restitution.The Journal of clinical investigation · 1997Article
- Direct intratumoral gene transfer of the herpes simplex virus thymidine kinase gene with DNA-liposome complexes: growth inhibition of tumors and lack of localization in normal tissues.Japanese journal of cancer research : Gann · 1997Article
- Effects of sex steroids and growth factors on migration and invasion of endometrial adenocarcinoma SNG-M cells in vitro.Japanese journal of cancer research : Gann · 1996Article
- In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals.Clinical & experimental metastasis · 1995Article
- Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis.The Journal of cell biology · 1994Article
- Interstitial collagenase gene expression in colonic neoplasia.The American journal of pathology · 1993Article
- Expression of amphiregulin, a novel gene of the epidermal growth factor family, in human gastric carcinomas.Japanese journal of cancer research : Gann · 1993Article
- Molecular mechanism of stomach carcinogenesis.Journal of cancer research and clinical oncology · 1993Article
- The architecture of cancer.BMJ (Clinical research ed.) · 1992Article
- A serine protease-inhibitory benzamidine derivative inhibits the growth of human colon carcinoma cells.Japanese journal of cancer research : Gann · 1992Article
- Expression of transforming growth factor alpha in human tissues: immunohistochemical study and northern blot analysis.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the effects of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) on EGF receptor (EGFR) phosphorylation and the expression of mRNAs for oncogenes, growth factors, their receptors and metalloproteinase genes by MKN-28 gastric carcinoma cells which express EGF, TGF-alpha and EGFR genes. Both EGF and TGF-alpha stimulated EGFR phosphorylation, EGF and TGF-alpha induced FOS, MYC and ERBB-2 oncogene expression. Interestingly, EGF increased the expression of mRNAs for TGF-alpha and EGFR. On the other hand, TGF-alpha increased TGF-alpha mRNA but decreased the expression of mRNAs for EGFR and TGF-beta. Furthermore, mRNAs for interstitial collagenase, stromelysin and procollagen type I genes were also enhanced after treatment with EGF and TGF-alpha. These results indicate that EGF and TGF-alpha successively evoke cascade phenomena which favor tumor progression, invasion and extracellular matrix formation, acting as autocrine growth regulators for gastric carcinomas.
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