ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Neurogenic Effects of Inorganic Arsenic and Cdk5 Knockdown in Zebrafish Embryos: A Perspective on Modeling Autism.International journal of molecular sciences · 2024Review
- A zebrafish-centric approach to antiepileptic drug development.Disease models & mechanisms · 2021Article
- Elevated Hoxb5b Expands Vagal Neural Crest Pool and Blocks Enteric Neuronal Development in Zebrafish.Frontiers in cell and developmental biology · 2021Article
- Vagus Motor Neuron Topographic Map Determined by Parallel Mechanisms of hox5 Expression and Time of Axon Initiation.Current biology : CB · 2017Article
- Behavioral Changes Over Time Following Ayahuasca Exposure in Zebrafish.Frontiers in behavioral neuroscience · 2017Article
- Animal models in epilepsy research: legacies and new directions.Nature neuroscience · 2015Review
- Zebrafish models for translational neuroscience research: from tank to bedside.Trends in neurosciences · 2014Review
- Notch signaling activation promotes seizure activity in temporal lobe epilepsy.Molecular neurobiology · 2014Article
- Zebrafish as an emerging model for studying complex brain disorders.Trends in pharmacological sciences · 2014Review
- Dynamic expression of neurexophilin1 during zebrafish embryonic development.Gene expression patterns : GEP · 2013Article
- Review
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Mutation within an ubiquitin E3 ligase gene can lead to a failure in Notch signaling, excessive neurons, and depletion of neural progenitor cells in mind bomb mutants. Using mib(hi904) zebrafish, we reported seizures and a down-regulation of γ-aminobutyric acid (GABA) signaling pathway genes. A transcriptome analysis also identified differential expression pattern of genes related to Notch signaling and neurodevelopment. Here, we selected nine of these genes (her4.2, hes5, bhlhb5, hoxa5a, hoxb5b, dmbx1a, dbx1a, nxph1, and plxnd1) and performed a more thorough analysis of expression using conventional polymerase chain reaction, real-time polymerase chain reaction and in situ hybridization. Transgenic reporter fish (Gfap:GFP and Dlx5a-6a:GFP) were used to assess early brain morphology in vivo. Down-regulation of many of these genes was prominent throughout key structures of the developing mib(hi904) zebrafish brain including, but not limited to, the pallium, ventral thalamus, and optic tectum. Brain expression of Dlx5a-6a and Gfap was also reduced. In conclusion, these expression studies indicate a general down-regulation of Notch signaling genes necessary for proper brain development and suggest that these mutant fish could provide valuable insights into neurological conditions, such as Angelman syndrome, associated with ubiquitin E3 ligase mutation.
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