ArticleJournal of neuroscience research2011
Slit-Robo signals regulate pioneer axon pathfinding of the tract of the postoptic commissure in the mammalian forebrain.
Article in Journal of neuroscience research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia.Respiratory research · 2020Article
- Enhanced FGFR3 activity in postmitotic principal neurons during brain development results in cortical dysplasia and axonal tract abnormality.Scientific reports · 2020Article
- Cell Development Deficiency and Gene Expression Dysregulation of Trisomy 21 Retina Revealed by Single-Nucleus RNA Sequencing.Frontiers in bioengineering and biotechnology · 2020Article
- Netrin-1/DCC-mediated PLCγ1 activation is required for axon guidance and brain structure development.EMBO reports · 2018Article
- Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling.Neural development · 2016Article
- Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion.Brain structure & function · 2016Article
- Involvement of Slit-Robo signaling in the development of the posterior commissure and concomitant swimming behavior in Xenopus laevis.Zoological letters · 2015Article
- Characterization of a mammalian prosencephalic functional plan.Frontiers in neuroanatomy · 2014Review
- Ascending midbrain dopaminergic axons require descending GAD65 axon fascicles for normal pathfinding.Frontiers in neuroanatomy · 2014Article
- Notch signaling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus.Frontiers in neuroanatomy · 2014Review
- Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development.Neural development · 2013Article
- Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling.Development (Cambridge, England) · 2012Article
- Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
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Abstract
During early vertebrate forebrain development, pioneer axons establish a symmetrical scaffold descending longitudinally through the rostral forebrain, thus forming the tract of the postoptic commissure (TPOC). In mouse embryos, this tract begins to appear at embryonic day 9.5 (E9.5) as a bundle of axons tightly constrained at a specific dorsoventral level. We have characterized the participation of the Slit chemorepellants and their Robo receptors in the control of TPOC axon projection. In E9.5-E11.5 mouse embryos, Robo1 and Robo2 are expressed in the nucleus origin of the TPOC (nTPOC), and Slit expression domains flank the TPOC trajectory. These findings suggested that these proteins are important factors in the dorsoventral positioning of the TPOC axons. Consistently with this role, Slit2 inhibited TPOC axon growth in collagen gel cultures, and interfering with Robo function in cultured embryos induced projection errors in TPOC axons. Moreover, absence of both Slit1 and Slit2 or Robo1 and Robo2 in mutant mouse embryos revealed aberrant TPOC trajectories, resulting in abnormal spreading of the tract and misprojections into both ventral and dorsal tissues. These results reveal that Slit-Robo signaling regulates the dorsoventral position of this pioneer tract in the developing forebrain.
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