ArticleClinical research in cardiology : official journal of the German Cardiac Society2011
Sympatho-renal axis in chronic disease.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.
- Impact of renal denervation on cardiac remodeling in resistant hypertension: A meta-analysis.Clinical cardiology · 2024Pooled it
- Blood pressure and the capacity-load model in 8-year-old children from Nepal: Testing the contributions of kidney size and intergenerational effects.American journal of human biology : the official journal of the Human Biology Council · 2016Trial
- Neuropeptide Y as an indicator of successful alterations in sympathetic nervous activity after renal sympathetic denervation.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Trial
- Beneficial effects of renal sympathetic denervation on cardiovascular inflammation and remodeling in essential hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Trial
- Catheter-based renal denervation for resistant hypertension: rationale and design of the SYMPLICITY HTN-3 Trial.Clinical cardiology · 2012Trial
- Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency.Cardiovascular revascularization medicine : including molecular interventionsTrial
- Clinical research progress of renal denervation for heart failure treatment: current evidence, controversies, and future directions.Frontiers in cardiovascular medicine · 2026Review
- The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined.Heart failure reviews · 2025Review
- The denervation or activation of renal sympathetic nerve and renal blood flow.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Review
- Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimer's disease.Frontiers in physiology · 2023Review
- A drug-induced hypotensive challenge to verify catheter-based radiofrequency renal denervation in an obese hypertensive swine model.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Article
- Pharmacotherapy for Essential Hypertension: A Brief Review.Methodist DeBakey cardiovascular journal · 2022Review
- The sympathies of the body: functional organization and neuronal differentiation in the peripheral sympathetic nervous system.Cell and tissue research · 2021Review
- Renal Denervation to Treat Heart Failure.Annual review of physiology · 2021Review
- Improving Diuretic Response in Heart Failure by Implementing a Patient-Tailored Variability and Chronotherapy-Guided Algorithm.Frontiers in cardiovascular medicine · 2021Review
- Role of comorbidities in heart failure prognosis Part 2: Chronic kidney disease, elevated serum uric acid.European journal of preventive cardiology · 2020Review
- Prediction and measurement of diuretic responsiveness after oral administration of furosemide to healthy dogs and dogs with congestive heart failure.Journal of veterinary internal medicine · 2020Article
- Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation.The journal of physiological sciences : JPS · 2020Article
- The regulation effect of WNT-RAS signaling in hypothalamic paraventricular nucleus on renal fibrosis.Journal of nephrology · 2020Article
- Increased Intra-Abdominal Pressure During Laparoscopic Pneumoperitoneum Enhances Albuminuria via Renal Venous Congestion, Illustrating Pathophysiological Aspects of High Output Preeclampsia.Journal of clinical medicine · 2020Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential hypertension, insulin resistance, heart failure, congestion, diuretic resistance, and functional renal disease are all characterized by excessive central sympathetic drive. The contribution of the kidney's somatic afferent nerves, as an underlying cause of elevated central sympathetic drive, and the consequences of excessive efferent sympathetic signals to the kidney itself, as well as other organs, identify the renal sympathetic nerves as a uniquely logical therapeutic target for diseases linked by excessive central sympathetic drive. Clinical studies of renal denervation in patients with resistant hypertension using an endovascular radiofrequency ablation methodology have exposed the sympathetic link between these conditions. Renal denervation could be expected to simultaneously affect blood pressure, insulin resistance, sleep disorders, congestion in heart failure, cardiorenal syndrome and diuretic resistance. The striking epidemiologic evidence for coexistence of these disorders suggests common causal pathways. Chronic activation of the sympathetic nervous system has been associated with components of the metabolic syndrome, such as blood pressure elevation, obesity, dyslipidemia, and impaired fasting glucose with hyperinsulinemia. Over 50% of patients with essential hypertension are hyperinsulinemic, regardless of whether they are untreated or in a stable program of treatment. Insulin resistance is related to sympathetic drive via a bidirectional mechanism. In this manuscript, we review the data that suggests that selective impairment of renal somatic afferent and sympathetic efferent nerves in patients with resistant hypertension both reduces markers of central sympathetic drive and favorably impacts diseases linked through central sympathetics-insulin resistance, heart failure, congestion, diuretic resistance, and cardiorenal disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.