ArticleBehavior genetics2012
Untreated hypertension decreases heritability of cognition in late middle age.
Article in Behavior genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Hypertension, sleep quality, depression, and cognitive function in elderly: A cross-sectional study.Frontiers in aging neuroscience · 2023Article
- Association between hypertension and cognitive function: A cross-sectional study in people over 45 years old in China.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Erectile dysfunction, vascular risk, and cognitive performance in late middle age.Psychology and aging · 2014Article
- Effects of hypertension and diabetes on sentence comprehension in aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2013Article
- Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men.NeuroImage · 2012Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Hypertension is a risk factor for cognitive decline, but the mechanisms underlying the effects of hypertension on cognition, particularly in midlife, are unclear. We examined whether hypertension modifies genetic influences on individual differences in cognition. Nine cognitive domains and general cognitive ability were assessed in a sample of 1,237 male twins aged 51-60 who were divided into three blood pressure groups: non-hypertensive; medicated hypertensive; and unmedicated hypertensive. Heritability was significantly lower among unmedicated hypertensives compared to medicated hypertensives and non-hypertensives for visual-spatial ability (p = 0.013) and episodic memory (p = 0.004). There were no heritability differences between non-hypertensives and medicated hypertensives. In addition, there were no significant differences in mean level cognition across the three blood pressure groups. These results suggest that in middle-aged men, untreated hypertension suppresses normal genetic influences on individual differences in certain domains of cognition prior to the emergence of hypertension-related effects on cognitive performance. These results further suggest that antihypertensive medication may protect against or reverse this effect.
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Registered trials
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