ReviewJournal of neural transmission (Vienna, Austria : 1996)2011
Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?-A Perspective Paper.Frontiers in psychiatry · 2018Article
- The association between gene variants and longitudinal structural brain changes in psychosis: a systematic review of longitudinal neuroimaging genetics studies.NPJ schizophrenia · 2017Review
- SorCS2 is required for BDNF-dependent plasticity in the hippocampus.Molecular psychiatry · 2016Article
- Neuregulin 1-induced AKT and ERK phosphorylation in patients with fragile X syndrome (FXS) and intellectual disability associated with obstetric complications.Journal of molecular neuroscience : MN · 2014Article
- Is catechol-o-methyltransferase gene polymorphism a risk factor in the development of premenstrual syndrome?Clinical and experimental reproductive medicine · 2014Article
- COMT and 5-HT1A-receptor genotypes potentially affect executive functions improvement after cognitive remediation in schizophrenia.Health psychology and behavioral medicine · 2014Article
- Early somatosensory processing in individuals at risk for developing psychoses.Frontiers in behavioral neuroscience · 2014Article
- Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample.Schizophrenia research · 2013Article
- GRIN2B gene and associated brain cortical white matter changes in bipolar disorder: a preliminary combined platform investigation.BioMed research international · 2013Article
- Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in schizophrenia.Behavioral neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies examining intermediate phenotypes such as neurocognitive and neuroanatomical measures along with susceptibility genes are important for improving our understanding of the neural basis of schizophrenia (SZ) and bipolar disorder (BD). In this paper, we review extant studies involving neurocognitive-genetic and neuroimaging-genetic perspectives and particularly related to catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin-1 (NRG1) genes in SZ and BD. In terms of neurocognitive-genetic investigations, COMT and BDNF are the two most studied candidate genes especially in patients with SZ. Whereas BDNF Met carriers perform worse on verbal working memory, problem solving and visuo-spatial abilities, COMT Met carriers perform better in working memory, attention, executive functioning with evidence of genotype by diagnosis interactions including high-risk individuals. In terms of genetic-structural MRI studies, patients with SZ are found to have reductions in the frontal, temporal, parietal cortices, and limbic regions, which are associated with BDNF, COMT, and NRGI genes. Genetic-functional MRI studies in psychotic disorders are sparse, especially with regard to BD. These neurocognitive and neuroimaging findings are associated with genes which are implicated in functional pathways related to neuronal signaling, inter-neuronal communication and neuroplasticity.
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