ArticleMolecular imaging and biology2012
Albumin-binding domain conjugate for near-infrared fluorescence lymphatic imaging.
Article in Molecular imaging and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Near-infrared fluorescence imaging for sentinel lymph node identification in colon cancer: a prospective single-center study and systematic review with meta-analysis.Techniques in coloproctology · 2019Pooled it
- Chromenylium Star Polymers: Merging Water Solubility and Stealth Properties with Shortwave Infrared Emissive Fluorophores.ACS central science · 2025Article
- Fluorescent Tracers forFrontiers in pharmacology · 2022Review
- Host-guest interactions of indocyanine green with β-cyclodextrin permit real-time characterization of the rat lymphatic system.JVS-vascular science · 2022Article
- Mixing Matrix-corrected Whole-body Pharmacokinetic Modeling Using Longitudinal Micro-computed Tomography and Fluorescence-mediated Tomography.Molecular imaging and biology · 2021Article
- New contrast agents for photoacoustic imaging and theranostics: Recent 5-year overview on phthalocyanine/naphthalocyanine-based nanoparticles.APL bioengineering · 2021Review
- A novel photoacoustic-fluorescent contrast agent for quantitative imaging of lymphatic drainage.Photoacoustics · 2021Article
- Characterization of focused ultrasound-mediated brainstem delivery of intranasally administered agents.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents.Contrast media & molecular imaging · 2019Article
- Direct loading of CTL epitopes onto MHC class I complexes on dendritic cell surface in vivo.Biomaterials · 2018Article
- Small Molecule Optoacoustic Contrast Agents: An Unexplored Avenue for Enhancing In Vivo Imaging.Molecules (Basel, Switzerland) · 2018Review
- Biomimetic 3D-printed neurovascular phantoms for near-infrared fluorescence imaging.Biomedical optics express · 2018Article
- Experimental Models Used to Assess Lymphatic Contractile Function.Lymphatic research and biology · 2017Review
- Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity.Scientific reports · 2016Article
- Lymph Node Transplantation Decreases Swelling and Restores Immune Responses in a Transgenic Model of Lymphedema.PloS one · 2016Article
- Imaging the lymphatic system.Microvascular research · 2014Review
- Emerging lymphatic imaging technologies for mouse and man.The Journal of clinical investigation · 2014Review
- Non-invasive optical imaging of the lymphatic vasculature of a mouse.Journal of visualized experiments : JoVE · 2013Article
- Differential transport function of lymphatic vessels in the rat tail model and the long-term effects of Indocyanine Green as assessed with near-infrared imaging.Frontiers in physiology · 2013Article
- Concentration of indocyanine green does not significantly influence lymphatic function as assessed by near-infrared imaging.Lymphatic research and biology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThe aim of this study was to develop and characterize a novel peptide imaging agent for noninvasive near-infrared fluorescence imaging of protein transport by the lymphatics. An imaging agent consisting of a cyclic albumin-binding domain (cABD) peptide, with sequence, Arg-Leu-Ile-Glu-Asp-Ile-Cys-Leu-Pro-Arg-Trp-Gly-Cys-Leu-Trp-Glu-Asp-Asp-Lys, was conjugated to a near-infrared fluorophore, IRDye800CW, allowing for enhanced vascular uptake, retention, and fluorescence imaging. PROCEDURE: Characterization of the cABD-IRDye800 peptide conjugate was performed using fluorescence spectroscopy to assess optical properties and SDS-PAGE and Biacore binding assays to determine binding affinity and specificity. Fluorescence imaging of normal C57BL/6 mice was conducted to monitor lymphatic uptake and retention.
resultscABD-IRDye800 exhibited approximately six times greater fluorescent yield and greater stability than indocyanine green, an agent previously used in humans to image lymphatic vasculature. The agent exhibited affinity for albumin with IC(50) and Kd in the nanomolar range and demonstrated superior retention characteristics within mouse lymphatics when compared with IRDye800CW.
conclusionscABD-IRDye800 has utility for assessing lymphatic function in mouse models of human lymphatic disease and the potential for use in clinical diagnostic imaging of the lymphatic vasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.