ArticleMolecular biology reports2012
Polymorphism of exon 2 of BoLA-DRB3 gene and its relationship with somatic cell score in Beijing Holstein cows.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Association Analysis ofAnimals : an open access journal from MDPI · 2025Article
- Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility.Frontiers in immunology · 2023Review
- Polymorphisms of the IL-17A Gene Influence Milk Production Traits and Somatic Cell Score in Chinese Holstein Cows.Bioengineering (Basel, Switzerland) · 2022Article
- Novel SNPs inJournal of animal science and biotechnology · 2017Article
- Bovine mastitis: frontiers in immunogenetics.Frontiers in immunology · 2014Review
- Haplotype analysis of TLR4 gene and its effects on milk somatic cell score in Chinese commercial cattle.Molecular biology reports · 2014Article
- Effect of BoLA-DRB3 exon2 polymorphisms on lameness of Chinese Holstein cows.Molecular biology reports · 2013Article
- SNPs identification and its correlation analysis with milk somatic cell score in bovine MBL1 gene.Molecular biology reports · 2013Article
- Association between BoLA-DRB3 and somatic cell count in Holstein cattle from Argentina.Molecular biology reports · 2012Article
- BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score.Molecular biology reports · 2012Article
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Authors and funding
10 authors.
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Abstract
In the present study, the exon 2 and 3' end sequence of intron 1 of BoLA-DRB3 gene of 211 Beijing Holstein cows was amplified and a uniform fragment of 284 bp was obtained. The genetic polymorphism was investigated by PCR-RFLP using two restriction endonucleases HaeIII and BstYI. Seven genotypes were detected by digesting the PCR products with HaeIII. The frequency of AA, AB, AC, AD, BB, BC and BF genotypes was 0.4638, 0.0193, 0.0193, 0.3478, 0.0290, 0.0386 and 0.0822, respectively. Three genotypes were found by digesting the PCR products with BstYI. The frequency of AA, AB and BB genotypes was 0.0569, 0.2844 and 0.6587, respectively. The relationship between the polymorphisms in exon 2 of BoLA-DRB3 gene and somatic cell score (SCS) in Beijing Holstein cows was analyzed by least squares linear model. No significant difference was detected among least squares means of SCS for seven HaeIII-RFLP genotypes (P > 0.05). As for BstYI-RFLP analysis, least squares mean of SCS for AA was significantly lower than that for AB (P < 0.05) or BB (P < 0.05), and no significant difference was detected between AB and BB genotypes (P > 0.05). BstYI AA was the most favorable genotype and BstYI BB was the most unfavorable genotype for mastitis resistance. The information found in the present study is very important for improving mastitis resistance in dairy cattle by marker assisted selection.
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