ArticleFrontiers in microbiology2010
A brief history of the antibiotic era: lessons learned and challenges for the future.
Article in Frontiers in microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06672471 (Post-Operative Antibiotic Efficacy in Clean Contaminated Head and Neck Surgery), which is not on this map. Cited by 521 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Post-Operative Antibiotic Efficacy in Clean Contaminated Head and Neck Surgery: A Randomized Controlled Trial
Who cites it
521 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review and meta-analysis of antimicrobial resistant bacteria in free-ranging wild mammals.BMC veterinary research · 2025Pooled it
- Global patterns of antibiotic resistance in group BFrontiers in microbiology · 2025Pooled it
- Markers of the ageing macrophage: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Novel Bacterial Topoisomerase Inhibitors: A New Front in an Old War.Journal of molecular biology · 2026Review
- Antimicrobial Resistance and Stewardship in Surgical Departments: A Three-Year Single-Center Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Climate change and antimicrobial resistance.Nature reviews. Microbiology · 2026Review
- Antibiotic-Induced Genotoxicity: Molecular Mechanisms, Cytogenetic Damage, and Implications for Human Health.International journal of molecular sciences · 2026Review
- Electrochemical technologies for removal of antibiotic resistance genes from wastewater: a comprehensive review of processes, mechanisms, and influencing factors.RSC advances · 2026Review
- Phage Therapy Enhanced by Using Engineered Bacteriophages: A Powerful Antibacterial Tool to Address the Dilemma Posed by Multidrug-Resistant Bacterial Infections.International journal of molecular sciences · 2026Review
- Chain-Length Regulation by WzzE Is Necessary for, but Genetically Separable From, Cyclic Enterobacterial Common Antigen Synthesis.Molecular microbiology · 2026Article
- Saturated fatty acids enhance daptomycin activity in a Fak-dependent manner in enterococci.Microbiology (Reading, England) · 2026Article
- Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules.Chemical Society reviews · 2026Review
- Advances in Dendrimer-Based Anti-Infective Systems: In Vivo Insights and Perspectives.Pharmaceutics · 2026Review
- Covalent Inhibitors in Antimicrobial Drug Development-Beyond β-Lactams.Molecules (Basel, Switzerland) · 2026Review
- Antibiotic Resistance: From the Bench to Patients, 2.0.Antibiotics (Basel, Switzerland) · 2026Article
- The Blessed Clay from Boho, Northern Ireland: Can the Nature of Spiritual Healing Sites Guide us Towards New Sources of Drug Discovery?Journal of religion and health · 2026Article
- BactProNET: a structural-mechanistic platform for interpreting target-mediated antimicrobial resistance.Scientific reports · 2026Article
- Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in street-vended tomato sauces in Dhaka, Bangladesh.BMC research notes · 2026Article
- Design of a multimodal synthetic peptide antibiotic derived from human cathelicidin.Cell biomaterials · 2026Article
- Empirical antibiotic use, resistance patterns, and their impact on clinical outcomes in a Yemeni tertiary hospital.New microbes and new infections · 2026Article
461 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article gives a very brief overview of the antibiotic era, beginning from the discovery of first antibiotics until the present day situation, which is marred by the emergence of hard-to-treat multiple antibiotic-resistant infections. The ways of responding to the antibiotic resistance challenges such as the development of novel strategies in the search for new antimicrobials, designing more effective preventive measures and, importantly, better understanding the ecology of antibiotics and antibiotic resistance are discussed. The expansion of conceptual frameworks based on recent developments in the field of antimicrobials, antibiotic resistance, and chemotherapy is also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.