ArticlePloS one2011
Zigzag turning preference of freely crawling cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Deriving the A/B Cells Policy as a Robust Multi-Object Cell Pipeline for Time-Lapse Microscopy.International journal of molecular sciences · 2025Article
- Active oscillations in microscale navigation.Animal cognition · 2023Review
- Shear-induced phenotypic transformation of microglia in vitro.Biophysical journal · 2023Article
- Oscillators and servomechanisms in orientation and navigation, and sometimes in cognition.Proceedings. Biological sciences · 2022Review
- Role of senescent cells in the motile behavior of active, non-senescent cells in confluent populations.Scientific reports · 2022Article
- Neighbor-enhanced diffusivity in dense, cohesive cell populations.PLoS computational biology · 2021Article
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- Hybrid mechanosensing system to generate the polarity needed for migration in fish keratocytes.Cell adhesion & migration · 2016Article
- Fast-crawling cell types migrate to avoid the direction of periodic substratum stretching.Cell adhesion & migration · 2016Article
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- Zigzag Generalized Lévy Walk: the In Vivo Search Strategy of Immunocytes.Theranostics · 2015Article
- Cancer-driven dynamics of immune cells in a microfluidic environment.Scientific reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coordinated motion of a cell is fundamental to many important biological processes such as development, wound healing, and phagocytosis. For eukaryotic cells, such as amoebae or animal cells, the cell motility is based on crawling and involves a complex set of internal biochemical events. A recent study reported very interesting crawling behavior of single cell amoeba: in the absence of an external cue, free amoebae move randomly with a noisy, yet, discernible sequence of 'run-and-turns' analogous to the 'run-and-tumbles' of swimming bacteria. Interestingly, amoeboid trajectories favor zigzag turns. In other words, the cells bias their crawling by making a turn in the opposite direction to a previous turn. This property enhances the long range directional persistence of the moving trajectories. This study proposes that such a zigzag crawling behavior can be a general property of any crawling cells by demonstrating that 1) microglia, which are the immune cells of the brain, and 2) a simple rule-based model cell, which incorporates the actual biochemistry and mechanics behind cell crawling, both exhibit similar type of crawling behavior. Almost all legged animals walk by alternating their feet. Similarly, all crawling cells appear to move forward by alternating the direction of their movement, even though the regularity and degree of zigzag preference vary from one type to the other.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.