ArticlePloS one2011
Dinosaur peptides suggest mechanisms of protein survival.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- Evidence for Endogenous Collagen inAnalytical chemistry · 2025Article
- Taphonomic variation in vascular remains from Mesozoic non-avian dinosaurs.Scientific reports · 2025Article
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- Independent Evidence for the Preservation of Endogenous Bone Biochemistry in a Specimen ofBiology · 2023Article
- Article
- Article
- Proteins, possibly human, found in World War II concentration camp artifact.Scientific reports · 2022Article
- Article
- A fossil protein chimera; difficulties in discriminating dinosaur peptide sequences from modern cross-contamination.Proceedings. Biological sciences · 2017Article
- Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein.Journal of proteome research · 2017Article
- Resurrecting the Dead (Molecules).Computational and structural biotechnology journal · 2017Review
- Peptide sequences from the first Castoroides ohioensis skull and the utility of old museum collections for palaeoproteomics.Proceedings. Biological sciences · 2016Article
- Chemistry supports the identification of gender-specific reproductive tissue in Tyrannosaurus rex.Scientific reports · 2016Article
- Biologically and diagenetically derived peptide modifications in moa collagens.Proceedings. Biological sciences · 2015Article
- Body fluid identification by mass spectrometry.International journal of legal medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
Abstract
Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril derived from extant taxa. The dinosaur peptides localized to fibril regions protected by the close packing of collagen molecules, and contained few acidic amino acids. Four peptides mapped to collagen regions crucial for cell-collagen interactions and tissue development. Dinosaur peptides were not represented in more exposed parts of the collagen fibril or regions mediating intermolecular cross-linking. Thus functionally significant regions of collagen fibrils that are physically shielded within the fibril may be preferentially preserved in fossils. These results show empirically that structure-function relationships at the molecular level could contribute to selective preservation in fossilized vertebrate remains across geological time, suggest a 'preservation motif', and bolster current concepts linking collagen structure to biological function. This non-random distribution supports the hypothesis that the peptides are produced by the extinct organisms and suggests a chemical mechanism for survival.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.