ArticlePloS one2011
Genetic and physiological analysis of iron biofortification in maize kernels.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Genetic Variation and Quantitative Trait Loci Analysis of the Maize Ionome in Response to Phosphorus Fertilisation.Plant, cell & environment · 2025Article
- Associations Between Mineral Composition and Aflatoxin B1 in Maize (Foods (Basel, Switzerland) · 2025Article
- Dissecting the genetic architecture of polygenic nutritional traits in maize through meta-QTL analysis.Food chemistry. Molecular sciences · 2025Article
- Biofortification of baby corn: Integrating agronomic and genetic approaches to address zinc micronutrient deficiencies - global perspectives and future challenges.Frontiers in plant science · 2025Review
- Mineral nutrients in plants under changing environments: A road to future food and nutrition security.The plant genome · 2023Review
- Iron bioavailability of maize (Frontiers in plant science · 2023Article
- Quantitative trait loci and candidate genes for iron and zinc bio-fortification in genetically diverse germplasm of maize (Heliyon · 2022Review
- Development of β-carotene, lysine, and tryptophan-rich maize (Zea mays) inbreds through marker-assisted gene pyramiding.Scientific reports · 2022Article
- Mapping of the Quantitative Trait Loci and Candidate Genes Associated With Iron Efficiency in Maize.Frontiers in plant science · 2022Article
- Genetic determinants of micronutrient traits in graminaceous crops to combat hidden hunger.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- High-resolution genome-wide association study pinpoints metal transporter and chelator genes involved in the genetic control of element levels in maize grain.G3 (Bethesda, Md.) · 2021Article
- Biofortification and bioavailability of Zn, Fe and Se in wheat: present status and future prospects.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- Iron Biofortification of Staple Crops: Lessons and Challenges in Plant Genetics.Plant & cell physiology · 2019Review
- Article
- Identification and validation of genomic regions influencing kernel zinc and iron in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Iron Retention in Root Hemicelluloses Causes Genotypic Variability in the Tolerance to Iron Deficiency-Induced Chlorosis in Maize.Frontiers in plant science · 2018Article
- Genetic Basis and Breeding Perspectives of Grain Iron and Zinc Enrichment in Cereals.Frontiers in plant science · 2018Review
- Iron Bioavailability Studies of the First Generation of Iron-Biofortified Beans Released in Rwanda.Nutrients · 2017Article
- The Interaction of Genotype and Environment Determines Variation in the Maize Kernel Ionome.G3 (Bethesda, Md.) · 2016Article
- Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaize is a major cereal crop widely consumed in developing countries, which have a high prevalence of iron (Fe) deficiency anemia. The major cause of Fe deficiency in these countries is inadequate intake of bioavailable Fe, where poverty is a major factor. Therefore, biofortification of maize by increasing Fe concentration and or bioavailability has great potential to alleviate this deficiency. Maize is also a model system for genomic research and thus allows the opportunity for gene discovery. Here we describe an integrated genetic and physiological analysis of Fe nutrition in maize kernels, to identify loci that influence grain Fe concentration and bioavailability. METHODOLOGY: Quantitative trait locus (QTL) analysis was used to dissect grain Fe concentration (FeGC) and Fe bioavailability (FeGB) from the Intermated B73 × Mo17 (IBM) recombinant inbred (RI) population. FeGC was determined by ion coupled argon plasma emission spectroscopy (ICP). FeGB was determined by an in vitro digestion/Caco-2 cell line bioassay.
conclusionsThree modest QTL for FeGC were detected, in spite of high heritability. This suggests that FeGC is controlled by many small QTL, which may make it a challenging trait to improve by marker assisted breeding. Ten QTL for FeGB were identified and explained 54% of the variance observed in samples from a single year/location. Three of the largest FeGB QTL were isolated in sister derived lines and their effect was observed in three subsequent seasons in New York. Single season evaluations were also made at six other sites around North America, suggesting the enhancement of FeGB was not specific to our farm site. FeGB was not correlated with FeGC or phytic acid, suggesting that novel regulators of Fe nutrition are responsible for the differences observed. Our results indicate that iron biofortification of maize grain is achievable using specialized phenotyping tools and conventional plant breeding techniques.
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