ArticleAutoimmune diseases2011
Primary biliary cirrhosis: family stories.
Article in Autoimmune diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Pooled it
- Autoantibodies in the diagnostics, prognostics and follow-up of primary biliary cholangitis.Journal of translational autoimmunity · 2026Review
- The Epidemiology of UK Autoimmune Liver Disease Varies With Geographic Latitude.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Article
- The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator?Canadian journal of gastroenterology & hepatology · 2018Review
- Evidence from a familial case suggests maternal inheritance of primary biliary cholangitis.World journal of gastroenterology · 2017Article
- Familial occurrence of autoimmune liver disease with overlapping features of primary biliary cholangitis and autoimmune hepatitis in a mother and her daughter.Clinical journal of gastroenterology · 2016Article
- Xenobiotics and loss of tolerance in primary biliary cholangitis.World journal of gastroenterology · 2016Review
- Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis.World journal of gastroenterology · 2015Review
- Article
- Tracing environmental markers of autoimmunity: introducing the infectome.Immunologic research · 2013Review
- Infectome: a platform to trace infectious triggers of autoimmunity.Autoimmunity reviews · 2013Review
- Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA.Journal of autoimmunity · 2013Article
- Potential Roles for Infectious Agents in the Pathophysiology of Primary Biliary Cirrhosis: What's New?Current infectious disease reports · 2013Article
- Popular and unpopular infectious agents linked to primary biliary cirrhosis.Auto- immunity highlights · 2012Review
- Predicting and preventing autoimmunity: the case of anti-mitochondrial antibodies.Auto- immunity highlights · 2012Review
- Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis?Trends in molecular medicine · 2012Article
- Role for mycobacterial infection in pathogenesis of primary biliary cirrhosis?World journal of gastroenterology · 2012Review
- Autoimmune hepatitis type 2 associated with an unexpected and transient presence of primary biliary cirrhosis-specific antimitochondrial antibodies: a case study and review of the literature.BMC gastroenterology · 2012Review
- Towards systemic sclerosis and away from primary biliary cirrhosis: the case of PTPN22.Auto- immunity highlights · 2012Review
- Epstein-barr virus as a trigger of autoimmune liver diseases.Advances in virology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary biliary cirrhosis (PBC) is a chronic immune-mediated cholestatic liver disease of unknown aetiology which affects mostly women in middle age. Familial PBC is when PBC affects more than one member of the same family, and data suggest that first-degree relatives of PBC patients have an increased risk of developing the disease. Most often, these familial clusters involve mother-daughter pairs, which is consistent with the female preponderance of the disease. These clusters provide evidence towards a genetic basis underlying PBC. However, clusters of nonrelated individuals have also been reported, giving strength to an environmental component. Twin studies have demonstrated a high concordance for PBC in monozygotic twins and a low concordance among dizygotic twins. In conclusion, studies of PBC in families clearly demonstrate that genetic, epigenetic, and environmental factors play a role in the development of the disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.