ArticlePloS one2011
Predicting housekeeping genes based on Fourier analysis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- A new gene tree algorithm employing DNA sequences of bovine genome using discrete Fourier transformation.PloS one · 2023Article
- Predicting plant growth response under fluctuating temperature by carbon balance modelling.Communications biology · 2022Article
- Article
- Conservation and Diversification of Circadian Rhythmicity Between a Model Crassulacean Acid Metabolism PlantFrontiers in plant science · 2018Article
- Valid application of western blotting.Molecular biology reports · 2014Article
- Partitioning the human transcriptome using HKera, a novel classifier of housekeeping and tissue-specific genes.PloS one · 2013Article
- PaGenBase: a pattern gene database for the global and dynamic understanding of gene function.PloS one · 2013Article
- Long non-coding RNAs function annotation: a global prediction method based on bi-colored networks.Nucleic acids research · 2013Article
- PaGeFinder: quantitative identification of spatiotemporal pattern genes.Bioinformatics (Oxford, England) · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Housekeeping genes (HKGs) generally have fundamental functions in basic biochemical processes in organisms, and usually have relatively steady expression levels across various tissues. They play an important role in the normalization of microarray technology. Using Fourier analysis we transformed gene expression time-series from a Hela cell cycle gene expression dataset into Fourier spectra, and designed an effective computational method for discriminating between HKGs and non-HKGs using the support vector machine (SVM) supervised learning algorithm which can extract significant features of the spectra, providing a basis for identifying specific gene expression patterns. Using our method we identified 510 human HKGs, and then validated them by comparison with two independent sets of tissue expression profiles. Results showed that our predicted HKG set is more reliable than three previously identified sets of HKGs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.