ArticleCritical care research and practice2011
Impact of a Multimodal Antimicrobial Stewardship Program on Pseudomonas aeruginosa Susceptibility and Antimicrobial Use in the Intensive Care Unit Setting.
Article in Critical care research and practice, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cycling empirical antibiotic therapy in hospitals: meta-analysis and models.PLoS pathogens · 2014Pooled it
- Hospitalised patients as stewards of their own antibiotic therapy: a qualitative analysis informing the strategic design of interventions to encourage shared decision-making in tertiary hospital settings in Singapore.Frontiers in public health · 2024Article
- Characteristics ofAntimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Carbapenem-ResistantMicroorganisms · 2023Article
- Do Inpatient Antimicrobial Stewardship Programs Help Us in the Battle Against Antimicrobial Resistance?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Minimal impact of selective susceptibility reporting on the use of piperacillin-tazobactam forInfection control and hospital epidemiology · 2021Article
- Impact of an antimicrobial stewardship programme on antimicrobial utilization and the prevalence of MDRJAC-antimicrobial resistance · 2020Article
- A Before-and-After Study of the Effectiveness of an Antimicrobial Stewardship Program in Critical Care.Antimicrobial agents and chemotherapy · 2018Article
- A 72-h intervention for improvement of the rate of optimal antibiotic therapy in patients with bloodstream infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Antimicrobial Stewardship: How the Microbiology Laboratory Can Right the Ship.Clinical microbiology reviews · 2017Review
- Determinants of Deescalation Failure in Critically Ill Patients with Sepsis: A Prospective Cohort Study.Critical care research and practice · 2016Article
- Antibiotic Susceptibilities of Pseudomonas aeruginosa Isolated from Blood Samples and Antibiotic Utilization in a University Hospital in Japan.Infectious diseases and therapy · 2015Article
- Antibiotic stewardship programmes in intensive care units: Why, how, and where are they leading us.World journal of critical care medicine · 2015Review
- Use of computer decision support in an antimicrobial stewardship program (ASP).Applied clinical informatics · 2015Article
- Optimizing antimicrobial therapy in critically ill patients.Infection and drug resistance · 2014Review
- Surveillance and correlation of antimicrobial usage and resistance of Pseudomonas aeruginosa: a hospital population-based study.PloS one · 2013Article
- In vitro and in vivo activities of ticarcillin-loaded nanoliposomes with different surface charges against Pseudomonas aeruginosa (ATCC 29248).Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective. To study the impact of our multimodal antibiotic stewardship program on Pseudomonas aeruginosa susceptibility and antibiotic use in the intensive care unit (ICU) setting. Methods. Our stewardship program employed the key tenants of published antimicrobial stewardship guidelines. These included prospective audits with intervention and feedback, formulary restriction with preauthorization, educational conferences, guidelines for use, antimicrobial cycling, and de-escalation of therapy. ICU antibiotic use was measured and expressed as defined daily doses (DDD) per 1,000 patient-days. Results. Certain temporal relationships between antibiotic use and ICU resistance patterns appeared to be affected by our antibiotic stewardship program. In particular, the ICU use of intravenous ciprofloxacin and ceftazidime declined from 148 and 62.5 DDD/1,000 patient-days to 40.0 and 24.5, respectively, during 2004 to 2007. An increase in the use of these agents and resistance to these agents was witnessed during 2008-2010. Despite variability in antibiotic usage from the stewardship efforts, we were overall unable to show statistical relationships with P. aeruginosa resistance rate. Conclusion. Antibiotic resistance in the ICU setting is complex. Multimodal stewardship efforts attempt to prevent resistance, but such programs clearly have their limits.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.