ArticleJournal of parasitology research2011
Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice.
Article in Journal of parasitology research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Lymphotoxin beta receptorInfection and immunity · 2025Article
- The type 2 immune response in gut homeostasis and parasite transmission in malaria.Trends in parasitology · 2025Review
- Current understanding of the immune potential of B-cell subsets in malarial pathogenesis.Frontiers in microbiology · 2023Review
- The spleen: "epicenter" in malaria infection and immunity.Journal of leukocyte biology · 2021Review
- Plasmodium asexual growth and sexual development in the haematopoietic niche of the host.Nature reviews. Microbiology · 2020Review
- B-cell memory in malaria: Myths and realities.Immunological reviews · 2020Review
- Humoral Immunity vs.Frontiers in immunology · 2019Review
- Antibody responses to α-Gal in African children vary with age and site and are associated with malaria protection.Scientific reports · 2018Article
- To B or Not to B: Understanding B Cell Responses in the Development of Malaria Infection.Frontiers in immunology · 2018Review
- IL-17 Promotes Differentiation of Splenic LSKJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Immunogenicity of the Plasmodium vivax merozoite surface protein 1 paralog in the induction of naturally acquired antibody and memory B cell responses.Malaria journal · 2017Article
- African Trypanosomes Undermine Humoral Responses and Vaccine Development: Link with Inflammatory Responses?Frontiers in immunology · 2017Review
- The chemokine CXCL12 mediates the anti-amyloidogenic action of painless human nerve growth factor.Brain : a journal of neurology · 2017Article
- Article
- An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- B cell sub-types following acute malaria and associations with clinical immunity.Malaria journal · 2016Article
- Pathogen manipulation of B cells: the best defence is a good offence.Nature reviews. Microbiology · 2015Review
- Plasmodium falciparum malaria and invasive bacterial co-infection in young African children: the dysfunctional spleen hypothesis.Malaria journal · 2014Review
- BAFF and BAFF receptor levels correlate with B cell subset activation and redistribution in controlled human malaria infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Recovery of an antiviral antibody response following attrition caused by unrelated infection.PLoS pathogens · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B cells and antibodies are essential for the protective immune response against a blood-stage Plasmodium infection. Although extensive research has focused on memory as well as plasma B-cell responses during infection, little is known about how malaria affects B-cell development and splenic maturation into marginal zone B (MZB) and follicular B (FoB) cells. In this study, we show that acute Plasmodium chabaudi AS infection in C57Bl/6 mice causes severe disruption of B lymphopoiesis in the bone marrow, affecting in particular pro-, pre-, and immature B cells as well as the expression of the bone marrow B-cell retention chemokine CXCL12. In addition, elevated apoptosis of transitional T2 and marginal zone (MZ) B cells was observed during and subsequent to the control of the first wave of parasitemia. In contrast, Folllicular (Fo) B cells levels were retained in the spleen throughout the infection, suggesting that these are essential for parasite clearance and proper infection control.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.