ArticleFrontiers in pharmacology2011
Human Urinary Bladder Strip Relaxation by the β-Adrenoceptor Agonist Isoprenaline: Methodological Considerations and Effects of Gender and Age.
Article in Frontiers in pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Nerve transfer for restoration of lower motor neuron-lesioned bladder, urethral, and anal sphincter function in a dog model. Part 3. nicotinic receptor characterization.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Article
- Dog and human bladders have different neurogenic and nicotinic responses in inner versus outer detrusor muscle layers.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Normalization of organ bath contraction data for tissue specimen size: does one approach fit all?Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Cardiac βBritish journal of pharmacology · 2019Review
- Urinary Bladder Weight and Function in a Rat Model of Mild Hyperglycemia and Its Treatment With Dapagliflozin.Frontiers in pharmacology · 2019Article
- Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle.BMC urology · 2015Article
- Contractile function of smooth muscle retained after overnight storage.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- β3-Adrenoceptor-mediated relaxation of rat and human urinary bladder: roles of BKCa channels and Rho kinase.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Changes in nerve-mediated contractility of the lower urinary tract in a mouse model of premature ageing.British journal of pharmacology · 2014Article
- Do β-adrenoceptor agonists induce homologous or heterologous desensitization in rat urinary bladder?Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- Sex differences in the physiology and pharmacology of the lower urinary tract.Current urology · 2013Review
- Functional investigation of β-adrenoceptors in human isolated detrusor focusing on the novel selective β3-adrenoceptor agonist KUC-7322.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
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3 authors.
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Abstract
The present study was primarily designed to explore various methodological aspects related to organ bath experiments evaluating human detrusor relaxation by the β-adrenoceptor agonist isoprenaline. Data are based upon a series of 30 consecutive patients, and this cohort was also used to explore possible effects of gender and age. KCl-induced contraction was related to strip length but not weight or cross-sectional area, indicating that the former is most suitable for data normalization. Storage of detrusor strips in cold buffer for up to 2 days did not affect contractile responses to KCl or efficacy of isoprenaline to cause relaxation but significantly affected the isoprenaline potency. No such alterations were observed with up to 1 day of cold storage. The type (KCl vs. passive tension) or strength of contractile stimulus had only minor effects on isoprenaline responses although these differences reached statistical significance in some cases. Similarly, gender and age had only minor if any effects on KCl-induced contraction or isoprenaline-induced relaxation, but the current data are too limited for robust conclusions. In summary we have evaluated experimental conditions for the testing of human detrusor strip contraction and relaxation which should be useful for future larger studies.
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