ArticleFrontiers in microbiology2011
Striking a balance: modulation of host cell death pathways by legionella pneumophila.
Article in Frontiers in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Inflammatory Patterns Associated withPathogens (Basel, Switzerland) · 2024Article
- Differential Bacterial Predation by Free-Living Amoebae May Result in Blooms ofMicroorganisms · 2021Article
- Strategies Used by Bacteria to Grow in Macrophages.Microbiology spectrum · 2016Review
- Selective requirement of the shikimate pathway of Legionella pneumophila for intravacuolar growth within human macrophages but not within Acanthamoeba.Infection and immunity · 2015Article
- Subversion of Cell-Autonomous Immunity and Cell Migration by Legionella pneumophila Effectors.Frontiers in immunology · 2015Review
- Rapid nutritional remodeling of the host cell upon attachment of Legionella pneumophila.Infection and immunity · 2014Article
- Article
- Nutrient generation and retrieval from the host cell cytosol by intra-vacuolar Legionella pneumophila.Frontiers in cellular and infection microbiology · 2014Review
- The transcriptome of Legionella pneumophila-infected human monocyte-derived macrophages.PloS one · 2014Article
- Induction of caspase 3 activation by multiple Legionella pneumophila Dot/Icm substrates.Cellular microbiology · 2013Article
- Induction of rapid cell death by an environmental isolate of Legionella pneumophila in mouse macrophages.Infection and immunity · 2013Article
- Review
- Legionella pneumophila transcriptional response following exposure to CuO nanoparticles.Applied and environmental microbiology · 2013Article
- Cell biology of infection by Legionella pneumophila.Microbes and infection · 2013Review
- Legionella pneumophila infection of Drosophila S2 cells induces only minor changes in mitochondrial dynamics.PloS one · 2013Article
- Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella.Trends in microbiology · 2012Review
- Legionella: from protozoa to humans.Frontiers in microbiology · 2011Article
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1 author.
Funding
Abstract
Programmed cell death is considered the ultimate solution for the host to eliminate infected cells, leading to the abolishment of the niche for microbial replication and the ablation of infection. Thus, it is not surprising that successful pathogens have evolved diverse strategies to reprogram the cell death pathways for their proliferation. Using effector proteins translocated by the Dot/Icm type IV secretion system, the facultative intracellular pathogen Legionella pneumophila manipulates multiple host cellular processes to create a niche within host cells to support its replication. Investigation in the past decade has established that in mammalian cells this bacterium actively modulates two host cell death pathways, namely the canonical apoptotic pathway controlled by the mitochondrion and the pyroptotic pathway controlled by the Nod-like receptor Naip5 and the Ipaf inflammasome. In this review, I will discuss the recent progress in understanding the mechanisms the bacterium employs to interfere with these host cell death pathways and how such modulation contribute to the intracellular life cycle of the pathogen.
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