ArticleFrontiers in microbiology2011
Quinolone resistance: much more than predicted.
Article in Frontiers in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- Plasmid-mediated quinolone resistance (PMQR) among Enterobacteriales in Latin America: a systematic review.Molecular biology reports · 2020Pooled it
- Plasmid-Mediated Quinolone Resistance Genes inVeterinary sciences · 2026Article
- Combined inactivation of the SOS response with TCA fumarases and the adaptive response enhances antibiotic susceptibility againstFrontiers in microbiology · 2025Article
- Antimicrobial Resistance Genes and Clonal Relationships of Duck-DerivedMicroorganisms · 2024Article
- Revealing antibiotic resistance's ancient roots: insights from pristine ecosystems.Frontiers in microbiology · 2024Review
- Polyinfection in Fish Aeromoniasis: A Study of Co-IsolatedPathogens (Basel, Switzerland) · 2023Article
- Probiotic and functional potential of lactic acid bacteria isolated from pulque and evaluation of their safety for food applications.Frontiers in microbiology · 2023Article
- Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance.Antibiotics (Basel, Switzerland) · 2022Review
- Antimicrobial resistance ofFrontiers in microbiology · 2022Article
- Flavonoids as Inhibitors of Bacterial Efflux Pumps.Molecules (Basel, Switzerland) · 2021Review
- Antibiotic resistance in shellfish and major inland pollution sources in the drainage basin of Kamak Bay, Republic of Korea.Environmental monitoring and assessment · 2021Article
- Antibiotic Resistance and Phylogeny ofMicroorganisms · 2021Article
- Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance.Molecules (Basel, Switzerland) · 2020Review
- Genotypic antimicrobial resistance characterization of E. coli from dairy calves at high risk of respiratory disease administered enrofloxacin or tulathromycin.Scientific reports · 2020Article
- Membrane-Targeting Triphenylphosphonium Functionalized Ciprofloxacin for Methicillin-Resistant Staphylococcus aureus (MRSA).Antibiotics (Basel, Switzerland) · 2020Article
- Metagenomic Approaches to Analyze Antimicrobial Resistance: An Overview.Frontiers in genetics · 2020Review
- Genomics ofFrontiers in microbiology · 2020Article
- N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluation.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2018Article
- Effect of Benzalkonium Chloride Adaptation on Sensitivity to Antimicrobial Agents and Tolerance to Environmental Stresses inFrontiers in microbiology · 2018Article
- Molecular characterization of antimicrobial multi-drug resistance in non-typhoidal Salmonellae from chicken and clam in Mangalore, India.Journal of biomedical research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since quinolones are synthetic antibiotics, it was predicted that mutations in target genes would be the only mechanism through which resistance could be acquired, because there will not be quinolone-resistance genes in nature. Contrary to this prediction, a variety of elements ranging from efflux pumps, target-protecting proteins, and even quinolone-modifying enzymes have been shown to contribute to quinolone resistance. The finding of some of these elements in plasmids indicates that quinolone resistance can be transferable. As a result, there has been a developing interest on the reservoirs for quinolone-resistance genes and on the potential risks associated with the use of these antibiotics in non-clinical environments. As a matter of fact, plasmid-encoded, quinolone-resistance qnr genes originated in the chromosome of aquatic bacteria. Thus the use of quinolones in fish-farming might constitute a risk for the emergence of resistance. Failure to predict the development of quinolone resistance reinforces the need of taking into consideration the wide plasticity of biological systems for future predictions. This plasticity allows pathogens to deal with toxic compounds, including those with a synthetic origin as quinolones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.