ArticleSmall GTPases2011
Regulation of cell adhesion and migration in cortical neurons: Not only Rho but also Rab family small GTPases.
Article in Small GTPases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold.PLoS biology · 2023Article
- Crosstalk between the Rho and Rab family of small GTPases in neurodegenerative disorders.Frontiers in cellular neuroscience · 2023Review
- Engineering Tissues of the Central Nervous System: Interfacing Conductive Biomaterials with Neural Stem/Progenitor Cells.Advanced healthcare materials · 2022Review
- STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Alteration of the late endocytic pathway in Charcot-Marie-Tooth type 2B disease.Cellular and molecular life sciences : CMLS · 2021Article
- Molecular Mechanisms of Cadherin Function During Cortical Migration.Frontiers in cell and developmental biology · 2020Review
- Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.Cell adhesion & migration · 2019Article
- Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease.Cells · 2019Review
- Linking Cell Polarity to Cortical Development and Malformations.Frontiers in cellular neuroscience · 2019Review
- Rab23 Regulates Radial Migration of Projection Neurons via N-cadherin.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Characterization of the role of RILP in cell migration.European journal of histochemistry : EJH · 2017Article
- Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.Protein science : a publication of the Protein Society · 2017Article
- Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development.Frontiers in neuroscience · 2015Review
- Article
- Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.Development (Cambridge, England) · 2014Article
- Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders.Genes to cells : devoted to molecular & cellular mechanisms · 2013Review
- Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking.Nature communications · 2013Article
- Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Cell adhesion and its endocytic regulation in cell migration during neural development and cancer metastasis.International journal of molecular sciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence indicate that Rho family small GTPases, including RhoA, Rac1 and Cdc42, control cytoskeletal organization and cell adhesion, and thereby cell migration in vitro and in vivo. Recently, the involvement of other small GTPases, such as Rab and Arf family proteins in cell migration has also been evaluated. Rab5, Rab11 and Rab7, which regulate endocytosis, recycling and lysosomal degradation pathways, respectively, are shown to have essential roles in the migration of immature neurons during the development of cerebral cortex in vivo. These Rab proteins control distinct steps of neuronal migration through the regulation of N-cadherin-mediated cell adhesion. In this extra view paper, I will discuss the functions of Rho and Rab family small GTP ases in cell migration with particular focus on the migrating neurons in the developing cerebral cortex.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.