ArticleSmall GTPases2010
Integrating chemotaxis and contact-inhibition during collective cell migration: Small GTPases at work.
Article in Small GTPases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- A Microfabricated Branch Selection Platform for Quantitative Measurement of Leader-Follower Interaction Strength and Interaction Range in Collective Cell Migration.Micromachines · 2026Article
- Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications.Frontiers in cell and developmental biology · 2024Review
- Gibbs process distinguishes survival and reveals contact-inhibition genes in Glioblastoma multiforme.PloS one · 2023Article
- Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration.Biophysical journal · 2022Article
- Neuropeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA Activation.Frontiers in cell and developmental biology · 2020Article
- Microtubules: Evolving roles and critical cellular interactions.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Switching between individual and collective motility in B lymphocytes is controlled by cell-matrix adhesion and inter-cellular interactions.Scientific reports · 2018Article
- Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition.Scientific reports · 2017Article
- Mechanisms of Cell Polarization.Current opinion in systems biology · 2017Article
- Regulators of Metastasis Modulate the Migratory Response to Cell Contact under Spatial Confinement.Biophysical journal · 2016Article
- Molecular basis of contact inhibition of locomotion.Cellular and molecular life sciences : CMLS · 2016Review
- Signaling filopodia in vertebrate embryonic development.Cellular and molecular life sciences : CMLS · 2016Review
- The front and rear of collective cell migration.Nature reviews. Molecular cell biology · 2016Review
- Atypical RhoV and RhoU GTPases control development of the neural crest.Small GTPases · 2015Review
- Chicken trunk neural crest migration visualized with HNK1.Acta histochemica · 2015Article
- Neural crest migration: trailblazing ahead.F1000prime reports · 2015Review
- Article
- Pard3 regulates contact between neural crest cells and the timing of Schwann cell differentiation but is not essential for neural crest migration or myelination.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Small Rho GTPases in the control of cell shape and mobility.Cellular and molecular life sciences : CMLS · 2014Review
- Cytoplasmic protein methylation is essential for neural crest migration.The Journal of cell biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
For directional cell migration to occur cells must interpret guiding cues present in their environment. Chemotaxis based on negative or positive signals has been long thought as the main driving force of guided cell migration. However during collective cell migration cells do receive information from external signals but also upon interactions with their direct neighbours. These multiple inputs must be translated into intracellular reorganisation in order to promote efficient directional migration. Small GTPases, being involved in establishing cell polarity and regulating protrusive activity, are likely to play a central role in signal integration. Indeed, recent findings from our laboratory indicate that Contact-Inhibition of Locomotion controlled by N-Cadherin and chemotaxis dependent on Sdf1/Cxcr4 signaling converge towards regulation of the localized activity of RhoA and Rac1. All together they establish cell polarity and select well-oriented cell protrusions to ensure directional cell migration.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.