ReviewTransactions of the American Clinical and Climatological Association2011
Fever, hyperthermia, and the lung: it's all about context and timing.
Review in Transactions of the American Clinical and Climatological Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Development and validation of a predictive model for pulmonary infection risk in patients with traumatic brain injury in the ICU: a retrospective cohort study based on MIMIC-IV.BMJ open respiratory research · 2024Article
- Article
- Fever-Range Hyperthermia Promotes Macrophage Polarization towards Regulatory Phenotype M2b.International journal of molecular sciences · 2023Article
- Evaluation of reticulorumen temperature boluses for the diagnosis of subclinical cases of bovine respiratory disease in feedlot cattle.Journal of animal science · 2021Article
- Artificial intelligence-enabled Internet of Things-based system for COVID-19 screening using aerial thermal imaging.Future generations computer systems : FGCS · 2021Article
- Successful use of mild therapeutic hypothermia as compassionate treatment for severe refractory hypoxemia in COVID-19.Journal of critical care · 2021Article
- Short-Term Fever-Range Hyperthermia Accelerates NETosis and Reduces Pro-inflammatory Cytokine Secretion by Human Neutrophils.Frontiers in immunology · 2019Article
- Integrative Physiology of Pneumonia.Physiological reviews · 2018Review
- Shifts in temperature within the physiologic range modify strand-specific expression of select human microRNAs.RNA (New York, N.Y.) · 2015Article
- Pyrexia: An update on importance in clinical practice.Indian journal of anaesthesia · 2015Article
- Article
- Highly pathogenic porcine reproductive and respiratory syndrome virus induces prostaglandin E2 production through cyclooxygenase 1, which is dependent on the ERK1/2-p-C/EBP-β pathway.Journal of virology · 2014Article
- Identification of fever and vaccine-associated gene interaction networks using ontology-based literature mining.Journal of biomedical semantics · 2012Article
- Hyperthermia promotes and prevents respiratory epithelial apoptosis through distinct mechanisms.American journal of respiratory cell and molecular biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although body temperature is tightly regulated in humans, elevated temperatures are frequently encountered during febrile illnesses and exertional and environmental hyperthermia. Such temperature increases exert profound effects on cell signaling and gene expression patterns, which have important consequences for innate immune function and cell injury, apoptosis, and recovery. The lung offers a framework for understanding how these effects can either benefit or harm the host. We present data demonstrating that exposure to febrile-range hyperthermia (∼39.5 °C) exerts multiple biologic effects that converge on enhanced neutrophil recruitment to the lung, and describe the consequences of these effects for pathogen clearance and collateral tissue injury. We also discuss the influence of temperature on apoptosis in lung epithelium. Collectively, the data presented identify body temperature as a modifiable factor that exerts profound influence on the outcome of infection and injury.
Indexed as
Identifiers
21686207PMC3116334W229371863What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.