ArticleSmall GTPases2010
Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module.
Article in Small GTPases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- The immune-evasive proline-283 substitution in influenza nucleoprotein increases aggregation propensity without altering the native structure.Science advances · 2024Article
- Subcellular Localization of MxB Determines Its Antiviral Potential against Influenza A Virus.Journal of virology · 2020Article
- Equine Mx1 Restricts Influenza A Virus Replication by Targeting at Distinct Site of its Nucleoprotein.Viruses · 2019Article
- Mx1 in Hematopoietic Cells Protects against Thogoto Virus Infection.Journal of virology · 2019Article
- Molecular cloning, GTP recognition mechanism and tissue-specific expression profiling of myxovirus resistance (Mx) protein in Labeo rohita (Hamilton) after Poly I:C induction.Scientific reports · 2019Article
- Porcine Mx1 Protein Inhibits Classical Swine Fever Virus Replication by Targeting Nonstructural Protein NS5B.Journal of virology · 2018Article
- Structural insight into HIV-1 restriction by MxB.Cell host & microbe · 2014Article
- Mx proteins: antiviral gatekeepers that restrain the uninvited.Microbiology and molecular biology reviews : MMBR · 2013Review
- Dynamin assembly strategies and adaptor proteins in mitochondrial fission.Current biology : CB · 2013Review
- An evolutionary perspective on the broad antiviral specificity of MxA.Current opinion in microbiology · 2013Review
- Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.PLoS pathogens · 2013Article
- Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly.Journal of virology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dynamin-like MxA GTP ase (Myxovirus resistance protein 1) mediates cellular resistance against a wide range of viruses. MxA is composed of an amino-terminal G domain, a middle domain and a carboxy-terminal GTPase effector domain. We recently determined the structure of the middle domain and GTPase effector domain of MxA constituting an elongated helical stalk, and elucidated the mechanism how the stalk mediates formation of ring-like MxA oligomers. Here, we shortly review our work and discuss the MxA rings as functional units of a cellular module orchestrating and executing the antiviral response.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.