ReviewNature reviews. Neuroscience2011
From the stochasticity of molecular processes to the variability of synaptic transmission.
Review in Nature reviews. Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed.
- A thioredoxin-Serinc2-lipid signaling axis modulates mood-related behaviors in mice.Molecular psychiatry · 2026Article
- Enhanced axonal mitochondrial motility and neural activity-induced energy deficits destabilize synaptic transmission in models of bipolar disorder.Nature communications · 2026Article
- Bypass neural interfaces for paralysis: clinical translation, challenges and future directions.Journal of neuroengineering and rehabilitation · 2026Review
- Time course of visual plasticity following adult-onset deafness.Scientific reports · 2026Article
- Brain glucodynamic variability is an essential feature of the metabolism-cognition relationship.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A Resource for Exploring Regional Diversity in the Male Rat Brain Synaptic Proteome.Scientific data · 2025Article
- Multiple brain activation patterns for the same perceptual decision-making task.Nature communications · 2025Article
- Memristive Ion Dynamics to Enable Biorealistic Computing.Chemical reviews · 2025Review
- Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Low frequency independent components: Internal neuromarkers linking cortical LFPs to behavior.iScience · 2024Article
- Brain signatures indexing variation in internal processing during perceptual decision-making.iScience · 2023Article
- Enhanced synaptic protein visualization by multicolor super-resolution expansion microscopy.Neurophotonics · 2023Article
- A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics.eLife · 2023Article
- Article
- Cell anatomy and network input explain differences within but not between leech touch cells at two different locations.Frontiers in cellular neuroscience · 2023Article
- Alzheimer's disease as a fundamental disease of information processing systems: An information theory perspective.Frontiers in neuroscience · 2023Review
- Visually evoked potentials (VEPs) across the visual field in hearing and deaf cats.Frontiers in neuroscience · 2023Article
- Exploiting the molecular diversity of the synapse to investigate neuronal communication: A guide through the current toolkit.The European journal of neuroscience · 2022Review
- Unusual Mathematical Approaches Untangle Nervous Dynamics.Biomedicines · 2022Review
- Stimulus presentation can enhance spiking irregularity across subcortical and cortical regions.PLoS computational biology · 2022Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The variability of the postsynaptic response following a single action potential arises from two sources: the neurotransmitter release is probabilistic, and the postsynaptic response to neurotransmitter release has variable timing and amplitude. At individual synapses, the number of molecules of a given type that are involved in these processes is small enough that the stochastic (random) properties of molecular events cannot be neglected. How the stochasticity of molecular processes contributes to the variability of synaptic transmission, its sensitivity and its robustness to molecular fluctuations has important implications for our understanding of the mechanistic basis of synaptic transmission and of synaptic plasticity.
Indexed as
Identifiers
21685931What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.